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Identification and management of familial hypercholesterolaemia [CG71]

Measuring the use of this guidance

Recommendation: 1.1.8

A family history of premature coronary heart disease should always be assessed in a person being considered for a diagnosis of FH (see Simon Broome criteria in appendix E of the NICE guideline).

What was measured: Patients who had their family history of cardiac disease documented
Data collection end: December 2011
66.67%
Number that met the criteria: 54 / 81
Area covered: Local
Source: Taylor CA et al. (2013) Diagnosis and management of familial hypercholesterolaemia in a tertiary cardiac centre. Heart, Vol 99 suppl 2, ppA81-A82


Recommendation: 1.1.9

When considering a diagnosis of FH, healthcare professionals with expertise in FH should use standardised pedigree terminology to document, when possible, at least a three-generation pedigree. This should include relatives' age of onset of coronary heart disease, lipid concentrations and smoking history. For deceased relatives, the age and cause of death, and smoking history should be documented. If possible, the index individual should verify this information with other family members

What was measured: Patients with a positive family history of CHD who had documentation of their relative’s high cholesterol
Data collection end: December 2011
11%
Number that met the criteria: / 29
Area covered: Local
Source: Taylor CA et al. (2013) Diagnosis and management of familial hypercholesterolaemia in a tertiary cardiac centre. Heart, Vol 99 suppl 2, ppA81-A82


Recommendation: 1.3.1.20

Lipid-modifying drug therapy for a child or young person with FH should usually be considered by the age of 10 years. The decision to defer or offer lipid-modifying drug therapy for a child or young person should take into account: their age the age of onset of coronary heart disease within the family, and the presence of other cardiovascular risk factors, including their LDL-C concentration.

What was measured: The proportion of children with familial hypercholesterolaemia on statins.
Data collection end: November 2014
47.8%
Number that met the criteria: 111 / 232
Area covered: UK
Source: Ramaswami U, Cooper J, and Humphries S E. (2017). The UK Paediatric Familial Hypercholesterolaemia Register: Preliminary data. Archives of Disease in Childhood, 102, pp.255-260.



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