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Molecular testing strategies for Lynch syndrome in people with colorectal cancer [DG27]

Measuring the use of this guidance

Recommendation: 1.1

Offer testing to all people with colorectal cancer, when first diagnosed, using immunohistochemistry for mismatch repair proteins or microsatellite instability testing to identify tumours with deficient DNA mismatch repair, and to guide further sequential testing for Lynch syndrome (see 1.2 and 1.3). Do not wait for the results before starting treatment.

What was measured: Proportion of people with newly diagnosed colorectal cancer who received immunohistochemistry for mismatch repair proteins.
Data collection end: August 2018
Number that met the criteria: 198 / 203
Area covered: Local
Source: Cavazza, A., Radia, C., Harlow, C. et al. (2019) Experience of the implementation and outcomes of universal testing for Lynch syndrome in the United Kingdom. Colorectal Disease

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