A high-quality test accuracy study is needed for the BRAHMS sFlt‑1 Kryptor/BRAHMS PLGF plus Kryptor PE ratio test, using thresholds defined by the company, done in a population independent from that used to establish the test's thresholds, and with the test used as intended in the NHS.
Further research is recommended on repeat PLGF (placental growth factor)-based testing, with standard clinical assessment, in women presenting with suspected preterm pre-eclampsia, who have had a previous PLGF-based test result (see section 3.7). This should include:
exploring the different scenarios in which repeat testing may be indicated
the appropriate intervals between PLGF-based tests
the diagnostic accuracy of repeat PLGF-based testing in women with suspected preterm pre-eclampsia.
Further research is recommended into how well the tests work when women are pregnant with more than 1 baby to find out if different cut-offs are needed (see section 3.15).