The National Institute for Health and Clinical Excellence (NICE) issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on Tissue-cultured limbal stem cell allograft transplantation for regrowth of corneal epithelium.

The guidance was considered for reassessment in October 2010 and it was concluded that NICE will not be updating this guidance at this stage. However, if you believe there is new evidence which should warrant a review of our guidance, please contact us via the email address below.


Limbal Corneal tissue is obtained either from eyes donated to the hospital eye bank or living relatives. Small amounts of tissue are digested to break apart cells and these are grown and amplified in culture. Sheets of cells are transplanted to affected eyes.

Coding recommendations

C46.7 Transplant of corneal limbal cells

Note: Use a subsidiary code to identify type of graft (Y27)

Y27.2 Allograft to organ NOC