August 2016 - NICE is updating this guidance (see the in development page for information). The NHS should continue to follow the recommendations in this guidance until the update is complete.

The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on IRE for the treatment of pancreatic cancer.


Irreversible electroporation is a process that uses electrical pulses to kill cancer cells. It is applied directly to a pancreatic cancer tumour through special needles. The main difference between this procedure and thermal techniques for destroying tumours is that it does not produce extreme heat or cold. This means that it may cause less damage to healthy surrounding tissues than some other procedures.

Coding recommendations

J66.8 Other specified therapeutic percutaneous operations on pancreas

Y12.3 Electrochemotherapy to lesion of organ NOC

Y53.- Approach to organ under image control

In addition a code from the ICD-10 category C25 Malignant neoplasm of pancreas is assigned.

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