Sofosbuvir (also known as Sovaldi) is recommended as a possible treatment for adults with some types (called genotypes) of chronic hepatitis C. It is taken with other drugs (peginterferon alfa and ribavirin, or ribavirin alone). See table 1.
Table 1 Sofosbuvir treatment
|Type of hepatitis C||Sofosbuvir with peginterferon alfa and ribavirin||Sofosbuvir with ribavirin alone|
|Genotype 1||Recommended by NICE||Not recommended by NICE|
|Genotype 2||Not licensed||
Recommended only if:
Recommended only if:
|Recommended only if the person has cirrhosis and cannot have interferon.|
|Genotype 4, 5 or 6||Recommended only if the person has cirrhosis.||Not recommended by NICE|
What does this mean for me?
If sofosbuvir (with peginterferon alfa and ribavirin, or ribavirin alone) is recommended for you and your doctor thinks that it is the right treatment, you should be able to have the treatment on the NHS.
If you are not eligible for treatment as described above, you should be able to continue taking sofosbuvir (with peginterferon alfa and ribavirin, or ribavirin alone) until you and your doctor decide it is the right time to stop.
The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory Agency using the Yellow Card Scheme.
Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.