Amivantamab for treating EGFR exon 20 insertion mutation-positive advanced non-small-cell lung cancer after platinum-based chemotherapy

Amivantamab (Rybrevant, Janssen) is indicated for the 'treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) Exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy'.

The dosage schedule is available in the summary of product characteristics for amivantamab.

The list price for amivantamab is £1,079 per 50 mg vial (excluding VAT; BNF online, accessed October 2022).

The company has a commercial arrangement, which would have applied if the technology had been recommended.