Research recommendation(s) from an individual piece of guidance
|Guidance||Ovarian cancer: recognition and initial management|
|Date issued||April 2011|
Research recommendations coming out of this guidance
- Relationship between duration of symptoms of ovarian cancer and stage at diagnosis:- Further research should be undertaken on the relationship between the duration and frequency of symptoms in women with ovarian cancer before diagnosis, the stage of disease at diagnosis and subsequent survival.
- RMI I (risk of malignancy index I) threshold for women with suspected ovarian cancer:- Further research should be undertaken to determine the optimum RMI I threshold that should be applied in secondary care to guide the management of women with suspected ovarian cancer.
- Imaging in the diagnostic pathway for women with ovarian cancer:- Large multicentre case–control studies should be conducted to compare the accuracy of CT versus MRI for staging and for predicting optimal cytoreduction in women with ovarian cancer.
- The role of systematic retroperitoneal lymphadenectomy in the surgical treatment of ovarian cancer:- A prospective randomised trial should be undertaken to evaluate the therapeutic effect, associated risks and cost effectiveness of systematic retroperitoneal lymphadenectomy in women with ovarian cancer whose disease appears to be confined to the ovaries.
- The value of primary surgery for women with advanced ovarian cancer:- Research should be undertaken to determine the effectiveness of primary surgery for women with advanced ovarian cancer whose tumour cannot be fully excised.