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Headaches in over 12s: diagnosis and management

  • Clinical guideline
  • Reference number: CG150
  • Published:  19 September 2012
  • Last updated:  03 June 2025

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Research recommendations coming out of this guidance

  • Amitriptyline to prevent recurrent migraine:- Is amitriptyline a clinically and cost effective prophylactic treatment for recurrent migraine?

  • Pizotifen to prevent recurrent migraine:- Is pizotifen a clinically and cost effective prophylactic treatment for recurrent migraine?

  • Topiramate to prevent recurrent cluster headache:- Is topiramate a clinically and cost effective prophylactic treatment for recurrent cluster headache?

  • Psychological interventions to manage chronic headache disorders:- Does a psychological intervention such as cognitive behavioural therapy (CBT) improve headache outcomes and quality of life for people with chronic headache disorders?

  • Pharmacological treatments for headache prophylaxis to aid withdrawal treatment in medication overuse
    headache:- Does a course of steroid treatment or pharmacological treatments used for headache prophylaxis help people with medication overuse headaches withdraw from medication?

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