April 2018: Cautions in the guideline have been added to link to the MHRA's latest advice and resources on sodium valproate. Medicines containing valproate taken in pregnancy can cause malformations in 11% of babies and developmental disorders in 30–40% of children after birth. Valproate treatment must not be used in girls and women including in young girls below the age of puberty, unless alternative treatments are not suitable and unless the terms of the pregnancy prevention programme are met. This programme includes: assessment of patients for the potential of becoming pregnant; pregnancy tests; counselling patients about the risks of valproate treatment; explaining the need for effective contraception throughout treatment; regular (at least annual) reviews of treatment by a specialist, and completion of a risk acknowledgement form. In pregnancy, valproate is contraindicated and an alternative treatment should be decided on, with appropriate specialist consultation. See the MHRA toolkit to ensure female patients are better informed about the risks of taking valproate during pregnancy.
February 2017: Amended footnote to recommendation 1.1.8 to clarify use of generic pregabalin and off-label status.
October 2015: Title changed from 'Neuropathic pain - pharmacological management: The pharmacological management of neuropathic pain in adults in non-specialist settings' to 'Neuropathic pain in adults: pharmacological management in non-specialist settings' for clarity and consistency with other guidance on this topic.
November 2013: This guidance is an update of NICE guideline CG96 (published March 2010) and replaces it.