4 Research recommendations

4 Research recommendations

  • Which subgroups of adults and children with RTIs presenting in primary care settings are most likely to benefit from an immediate antibiotic prescribing strategy in terms of symptomatic management and prevention of complications?

  • What is the clinical and cost effectiveness of a delayed antibiotic prescribing strategy compared with both a no antibiotic prescribing strategy and an immediate antibiotic prescribing strategy for acute rhinosinusitis?

  • What is the clinical and cost effectiveness of differing methods of delivering a delayed antibiotic prescribing strategy in primary care for adults and children presenting with RTIs?

  • What are the rates of prescription, dispensing and complications in adults and children with RTIs when different delayed prescribing strategies or no prescribing are used, and how does any potential difference in risk of developing complications affect the cost effectiveness of a delayed antibiotic prescribing strategy or a no prescribing strategy?

  • Which clinical features of children and adults presenting in primary care with RTIs are associated with the development of serious complications and need for hospitalisation?

  • Do patients and parents/carers' preferences regarding antibiotic management strategies (immediate, delayed and no prescribing strategy) for RTIs differ according to ethnicity and socioeconomic status?

Health economics

  • How does a delayed prescribing strategy affect the risk of patients developing complications after an initial episode of RTI and how does this potential difference in risk affect the cost effectiveness of a delayed prescribing strategy?

  • Research is needed in assessing the health-related quality of life of people with RTIs, in particular when using generic measures such as the EQ-5D. In addition, further research is needed in applying health-related quality of life weights when investigating interventions for short-term illnesses such as RTIs.

  • National Institute for Health and Care Excellence (NICE)