About this guideline
NICE clinical guidelines are recommendations about the treatment and care of people with specific diseases and conditions.
NICE guidelines are developed in accordance with a scope that defines what the guideline will and will not cover.
The original guideline (published in 2010) was developed by the National Collaborating Centre for Acute and Chronic Conditions, which is based at the Royal College of Physicians. The Collaborating Centre worked with a Guideline Development Group, comprising healthcare professionals (including consultants, GPs and nurses), patients and carers, and technical staff, which reviewed the evidence and drafted the recommendations.
NICE's Clinical Guidelines Update Programme updated this guideline in 2015. These guidelines are updated using a Standing Committee of healthcare professionals, methodologists and lay members from a range of disciplines and localities.
The recommendations were finalised after public consultation.
The methods and processes for developing NICE clinical guidelines can be found here.
NICE produces guidance, standards and information on commissioning and providing high‑quality healthcare, social care, and public health services. We have agreements to provide certain NICE services to Wales, Scotland and Northern Ireland. Decisions on how NICE guidance and other products apply in those countries are made by ministers in the Welsh government, Scottish government, and Northern Ireland Executive. NICE guidance or other products may include references to organisations or people responsible for commissioning or providing care that may be relevant only to England.
Recommendations on mechanical prophylaxis for venous thromboembolism in patients who are admitted for stroke have been added to section 1.4. The addendum contains details of the methods and evidence used to update these recommendations.
Recommendations are marked as [new 2015] or :
[new 2015] indicates that the evidence has been reviewed and the recommendation has been added or updated
 indicates that the evidence has not been reviewed since 2010.
Some recommendations can be made with more certainty than others. The Guideline Development Group makes a recommendation based on the trade‑off between the benefits and harms of an intervention, taking into account the quality of the underpinning evidence. For some interventions, the Guideline Development Group is confident that, given the information it has looked at, most patients would choose the intervention. The wording used in the recommendations in this guideline denotes the certainty with which the recommendation is made (the strength of the recommendation).
For all recommendations, NICE expects that there is discussion with the patient about the risks and benefits of the interventions, and their values and preferences. This discussion aims to help them to reach a fully informed decision (see also patient-centred care).
We usually use 'must' or 'must not' only if there is a legal duty to apply the recommendation. Occasionally we use 'must' (or 'must not') if the consequences of not following the recommendation could be extremely serious or potentially life threatening.
We use 'offer' (and similar words such as 'refer' or 'advise') when we are confident that, for the vast majority of patients, an intervention will do more good than harm, and be cost effective. We use similar forms of words (for example, 'Do not offer…') when we are confident that an intervention will not be of benefit for most patients.
We use 'consider' when we are confident that an intervention will do more good than harm for most patients, and be cost effective, but other options may be similarly cost effective. The choice of intervention, and whether or not to have the intervention at all, is more likely to depend on the patient's values and preferences than for a strong recommendation, and so the healthcare professional should spend more time considering and discussing the options with the patient.
NICE began using this approach to denote the strength of recommendations in guidelines that started development after publication of the 2009 version of 'The guidelines manual' (January 2009). This does not apply to any recommendations ending  (see 'Update information' above for details about how recommendations are labelled). In particular, for recommendations labelled  the word 'consider' may not necessarily be used to denote the strength of the recommendation.
The full guideline, venous thromboembolism in adults admitted to hospital: reducing the risk, contains details of the methods and evidence used to develop the guideline. It is published by the National Collaborating Centre Acute and Chronic Conditions.
The addendum to the full guideline contains details of the methods and evidence used to develop the updated recommendations (labelled )
The recommendations from this guideline have been incorporated into a NICE pathway.
We have produced information for the public about this guideline.
Implementation tools and resources to help you put the guideline into practice are also available.