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NICE has assessed placental growth factor (PlGF)‑based testing to help diagnose pre‑eclampsia in women suspected of having the condition, so that the NHS can decide whether to use these products.

PlGF is a hormone that helps new blood vessels to grow in the placenta. In pre‑eclampsia, PlGF levels can be very low. PlGF‑based tests measure the PlGF levels in the mother’s blood. Women with pre‑eclampsia need monitoring in hospital.

NICE has said that in women, whom doctors think may have pre-eclampsia and who are between 20 weeks and 34 weeks plus 6 days’ gestation, the Triage PlGF test and the Elecsys immunoassay sFlt‑1/PlGF ratio with other diagnostic tests and follow‑up checks:

  • can be used in the NHS to help doctors decide that they do not have pre‑eclampsia
  • show promise in helping doctors to decide that they do have pre-eclampsia, but there was not enough evidence to recommend that these tests are used in the NHS.

NICE did not recommend the DELFIA Xpress PlGF 1‑2‑3 test or the BRAHMS sFlt‑1 Kryptor/BRAHMS PlGF plus Kryptor PE ratio because more evidence is needed.

ISBN: 978‑1‑4731‑1857‑7

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