4 Recommendations for further research

Guidance

4.1 Research is recommended on the prevalence of lung nodules in people who have a chest CT scan because of signs or symptoms that suggest lung cancer.

4.2 Research in, and outside of, targeted lung cancer screening is recommended on:

the accuracy of AI-Rad Companion Chest CT, AVIEW LCS+, ClearRead CT, contextflow SEARCH Lung CT, InferRead CT Lung, Lung AI, qCT‑Lung, SenseCare‑Lung Pro, Veolity, Veye Lung Nodules, and VUNO Med-LungCT AI plus clinician review compared with clinician review alone to detect, measure and assess the growth of lung nodules
the effect of using the software on clinical decision making
the effect of using the software on scan review and reporting time.

Studies should ideally compare more than 1 software and should report per-person results. They should also consider reporting data separately for subgroups, if using the technologies may be particularly useful or less effective for those subgroups. For example:
people with underlying lung conditions, and people whose family background means they are more likely to have subsolid nodules
scans reviewed by more experienced and less experienced reviewers
outside of targeted screening, people who had CT scans:
- with contrast
- without contrast.