As you will be aware, the Department for Health and Social Care has asked NICE to carry out a Single Technology Appraisal of ixazomib with lenalidomide and dexamethasone for untreated multiple myeloma. Following an update from the company, the timelines for this appraisal are to be confirmed whilst the company await the outcome of the next planned interim analysis of the ongoing TOURMALINE-MM2 trial being undertaken in this indication. NICE will continue to monitor development and will update interested parties as and when the situation changes.