As you will be aware, the Department for Health & Social Care has asked NICE to carry out a Single Technology Appraisal of Pembrolizumab with chemoradiotherapy for untreated unresectable oesophageal cancer [6270]. Please note that following on from advice received from the company, further information regarding the timelines for this appraisal will be available in due course. In the meantime, NICE will continue to monitor the situation and will provide an update as and when the situation changes