1 Recommendations

1 Recommendations

1.1 The evidence on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation raises no major safety concerns. However, current evidence on its efficacy is limited in quantity. Therefore, this procedure should only be used with special arrangements for clinical governance, consent, and audit or research.Find out what special arrangements mean on the NICE interventional procedures guidance page.

1.2 Clinicians wishing to do ex-situ machine perfusion for extracorporeal preservation of livers for transplantation should:

1.3 Clinicians and centres doing this procedure must follow the relevant regulatory and legal requirements of the Human Tissue Authority.

1.4 Clinicians should enter details about all patients having this procedure into the NHS Blood and Transplant UK transplant registry.

1.5 Further research should report the exact method of perfusion used (such as hypothermic or normothermic), graft survival and the use of marginal grafts.

  • National Institute for Health and Care Excellence (NICE)