Early and locally advanced breast cancer: diagnosis and management

Evidence reviews

The following document contains the evidence that was used to develop the January 2024 recommendations:

• Further surgery after breast-conserving surgery based on tissue margins

The following document contains the evidence that was used to develop the June 2023 recommendations:

• Effectiveness of different external beam hypofractionation radiotherapy regimens in people with early-stage or locally advanced invasive breast cancer

The following document contains the evidence that was used to develop the April 2023 recommendations:

• Strategies for reducing arm and shoulder problems after breast cancer surgery or radiotherapy

The following documents contain the evidence that was used to develop the July 2018 recommendations:

• Surgery to the breast
• Management of positive axilla
• Adjuvant systemic therapy planning
• Endocrine therapy
• Adjuvant chemotherapy
• Adjuvant biological therapy
• Adjuvant bisphosphonates
• Breast radiotherapy
• Postmastectomy ratiotherapy
• Neoadjuvant treatment
• Lifestyle

These documents preserve evidence reviews and committee discussions for areas of the guideline from 2009:

• Full guideline
• Evidence review

Other supporting evidence

• Methods
• Supplement 1: Health economics
• Supplement 2: NGA staff, glossary, abbreviations and equalities considerations
• Supplement 3: Algorithm