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Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management

  • NICE guideline
  • Reference number: NG206
  • Published:  29 October 2021
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Research recommendations coming out of this guidance

  • Diagnostic tests: What diagnostic tests are clinically and cost effective in people with suspected myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome (ME/CFS)?

  • A core outcome set: What core set of relevant health outcome measures should be used for trials of treatments for ME/CFS and managing symptoms of ME/CFS?

  • Diagnostic criteria: In people with suspected ME/CFS, how effective is the NICE 2021 consensus-based diagnostic criteria in identifying people with ME/CFS?

  • Self-monitoring management strategies: What is the clinical and cost effectiveness of self-monitoring strategies and techniques in guiding energy management?

  • Sleep management strategies: What is the clinical and cost effectiveness of sleep management strategies in managing ME/CFS?

  • Dietary strategies: What is the clinical and cost effectiveness of dietary strategies in managing ME/CFS?

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