1 Guidance

1 Guidance

1.1 Febuxostat, within its marketing authorisation, is recommended as an option for the management of chronic hyperuricaemia in gout only for people who are intolerant of allopurinol (as defined in section 1.2) or for whom allopurinol is contraindicated.

1.2 For the purposes of this guidance, intolerance of allopurinol is defined as adverse effects that are sufficiently severe to warrant its discontinuation, or to prevent full dose escalation for optimal effectiveness as appropriate within its marketing authorisation.

1.3 People currently receiving febuxostat should have the option to continue therapy until they and their clinicians consider it appropriate to stop.

  • National Institute for Health and Care Excellence (NICE)