Review Decision – April 2016
Review of NICE technology appraisal 259; Abiraterone for the treatment of metastatic, castrate-resistant prostate cancer following previous cytotoxic chemotherapy, and NICE technology appraisal 316; Enzalutamide for the treatment of hormone refractory prostate cancer
Decision to defer the review
The Institute has recently issued a Final Appraisal Determination (FAD) for ‘Abiraterone for the treatment of metastatic hormone relapsed prostate cancer not previously treated with chemotherapy’ [ID503]. In this FAD, abiraterone is recommended on the condition that a newly-agreed Patient Access Scheme is implemented by the company (Janssen).
The Patient Access Scheme agreed during the development of TA259 will be replaced by the newly-agreed Patient Access Scheme, and as such the cost-effectiveness of abiraterone in TA259 is likely to be affected.
Consequently we have decided to defer the consideration of a review of TA259 until further exploratory work has been carried out to determine whether the change in the PAS arrangements are likely to lead to a change in the existing recommendations in TA259.
TA316 is scheduled to be considered for review alongside TA259. As abiraterone is considered to be a comparator of enzalutamide, it remains appropriate for these two appraisals to be considered for review together. As a result, the review of TA316 will also be deferred.
The Institute will consult with stakeholders on any proposed changes to the existing guidance once the exploratory work has been carried out.
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