1 Guidance

1.1 Pembrolizumab is recommended as an option for treating advanced (unresectable or metastatic) melanoma in adults only:

  • after the disease has progressed with ipilimumab and, for BRAF V600 mutation‑positive disease, a BRAF or MEK inhibitor and

  • when the company provides pembrolizumab in line with the commercial access agreement with NHS England.

  • National Institute for Health and Care Excellence (NICE)