Information for the public

Collagenase clostridium histolyticum is available on the NHS. It is a possible treatment for Dupuytren’s contracture in adults with a palpable cord, if all of the following apply:

  • The person has moderate disease, with up to 2 affected joints.
  • A procedure called percutaneous needle fasciotomy is not appropriate, but limited fasciectomy is an option.
  • The risks and benefits of this treatment and the other options are discussed with the hand surgeon before deciding about treatment.
  • One injection is given per outpatient treatment session by the hand surgeon.

There is a clinical trial ongoing with collagenase clostridium histolyticum (HTA-15/102/04), comparing it with limited fasciectomy. You are encouraged to take part in the trial; talk to your doctor for more information.

If you are not eligible for collagenase clostridium histolyticum but are already taking it, you should be able to continue until you and your doctor decide when best to stop.

Is this treatment right for me?

Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. Read more about making decisions about your care.

Questions to think about

  • How well does it work compared with other treatments?
  • What are the risks or side effects? How likely are they?
  • How will the treatment affect my day-to-day life?
  • What happens if the treatment does not work?
  • What happens if I do not want to have treatment? Are there other treatments available?

Information and support

NHS Choices may be a good place to find out more.

This organisation can give you advice and support:

NICE is not responsible for the quality or accuracy of any information or advice provided by this organisation.

ISBN: 978-1-4731-2604-6


This page was last updated: 26 July 2017