1 Guidance

1 Guidance

This guidance replaces 'Glycoprotein IIb/IIIa inhibitors in the treatment of acute coronary syndromes' (Technology Appraisal Guidance No 12) issued in September 2000.

This guidance has been partially updated by 'Unstable angina and NSTEMI' (NICE clinical guideline 94) as shown below.

1.1 This recommendation no longer stands.

1.2 This recommendation has been updated and replaced by recommendation 1.3.9 in NICE clinical guideline 94.

1.3 This recommendation has been updated and replaced by recommendation 1.3.9 in NICE clinical guideline 94.

1.4 This recommendation has been updated and replaced by recommendations 1.2.1 and 1.2.2 in NICE clinical guideline 94.

1.5 This recommendation no longer stands.

1.6 This recommendation has been updated and replaced by recommendation 1.3.10 in NICE clinical guideline 94.

1.7 It is recommended that a GP IIb/IIIa inhibitor is considered as an adjunct to PCI for all patients with diabetes undergoing elective PCI, and for those patients undergoing complex procedures (for example, multi-vessel PCI, insertion of multiple stents, vein graft PCI or PCI for bifurcation lesions); currently only abciximab is licensed as an adjunct to PCI. In procedurally uncomplicated, elective PCI, where the risk of adverse sequelae is low, use of a GP IIb/IIIa inhibitor is not recommended unless unexpected immediate complications occur.

1.8 GP IIb/IIIa inhibitors are not currently licensed in the UK for use as an adjunct to thrombolytic therapy in ST-segment-elevation MI.