Table of Contents

1 Overview

2 Full preceding guidance TA89 - The use of ACI for the treatment of cartilage defects in the knee joints

3 Assessment Report prepared by Warwick Evidence

4 Assessment Report Addendum prepared by Warwick Evidence

5 Consultee and commentator comments on the Assessment Report from Sobi

6 Consultee and commentator comments on the Assessment Report from Healthcare Improvement Scotland

7 Company submission from AAstrom Biosciences

8 Company submission from Sobi

9 Company submission from Robert Jones & Agnes Hunt Orthopaedic & District Hospital NHS Trust

10 Professional group, patient group and NHS organisation submissions from BASK

11 Expert personal statements from John Keating

12 Expert personal statements from Professor Martyn Snow