Venetoclax (Venclyxto) is available through the Cancer Drugs Fund as a possible treatment for chronic lymphocytic leukaemia in adults if:
- they have a 17p deletion or TP53 mutation anda B-cell receptor pathway inhibitor is unsuitable, or if their disease has got worse after a B-cell receptor pathway inhibitor or
- they don’t have a 17p deletion or TP53 mutation, and their disease has got worse after both chemo-immunotherapy and a B-cell receptor pathway inhibitor.
More evidence on venetoclax is being collected, until December 2020. After this NICE will decide whether or not to recommend venetoclax for use on the NHS and update the guidance. It will be available through the Cancer Drugs Fund until then.
If you are not eligible for venetoclax but are already taking it, you should be able to continue until you and your doctor decide when best to stop.
Is this treatment right for me?
Your healthcare professionals should give you clear information, talk with you about your options and listen carefully to your views and concerns. Your family can be involved too, if you wish. Read more about making decisions about your care.
Questions to think about
- How well does it work compared with other treatments?
- What are the risks or side effects? How likely are they?
- How will the treatment affect my day-to-day life?
- What happens if the treatment does not work?
- What happens if I do not want to have treatment? Are there other treatments available?
Information and support
NHS Choices may be a good place to find out more.
These organisations can give you advice and support:
- Leukaemia Care, 08088 010 444
- Leukaemia Cancer Society, 0208 374 4821
- Bloodwise (previously Leukaemia & Lymphoma Research), 0808 2080 888
- CLL Support Association, 0800 977 4396
- Lymphoma Association, 0808 808 5555
You can also get support from your local Healthwatch.
NICE is not responsible for the quality or accuracy of any information or advice provided by these organisations.
This page was last updated: 08 November 2017