Suspended. Following a challenge to the decision to review sapropterin for treating phenylketonuria through the technology appraisal programme, NICE has made the exceptional decision to pause the appraisal at this point and ask the topic selection decision making panel to reconsider whether this topic is suitable for the NICE highly specialised technologies or technology appraisal programme. After this a formal referral will be required from the Minister to determine the process under which sapropterin will be assessed. An update will be provided once a formal referral is received.