The Department for Health and Social Care has asked NICE to conduct an appraisal of pegcetacoplan for previously treated paroxysmal nocturnal haemoglobinuria. Please note that following on from advice received from the company the timelines for this appraisal have been revised. We now anticipate that the appraisal will begin during mid-March 2021 when we will write to you about how you can get involved.