The Department of Health and Social Care has asked NICE to produce guidance on the above technology in the NHS in England. Over the past few months NICE has been working with the company and evidence review group on the evidence submission and critique. We have experienced some technical challenges during this process, which all parties have worked to resolve. These technical challenges have led to delays in the evidence generation. Therefore, to avoid further delay NICE, following discussion with the company, have decided not to hold a technical engagement for this appraisal. To avoid further delay we will proceed directly to a discussion at the scheduled committee meeting on 4 November 2021. We will endeavour to keep stakeholders informed if there are any further updates ahead of the committee meeting.