Recommendation ID

Epilepsy syndromes: What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

Any explanatory notes
(if applicable)

Despite the need to diagnose individual epilepsy syndromes, there is little evidence on the most appropriate initial or add-on AEDs in the treatment of the rarer epilepsies.

The research should include:

  • multicentre randomised controlled comparative trials with centralised national data collection

  • the ketogenic diet as one of the randomised treatments

  • primary outcome of seizure freedom

  • secondary outcomes, including seizure reduction, quality of life and cognitive outcome

  • an attempt to obtain data on pharmaco-resistance

  • the possibility of including all children with specific epilepsy syndromes for consideration in the trial.

Source guidance details

Comes from guidance
Epilepsies: diagnosis and management
Date issued
January 2012

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 31/05/2021