- Recommendation ID
What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?
- Any explanatory notes
Despite the need to diagnose individual epilepsy syndromes, there is little evidence on the most appropriate initial or add-on AEDs in the treatment of the rarer epilepsies.
The research should include:
multicentre randomised controlled comparative trials with centralised national data collection
the ketogenic diet as one of the randomised treatments
primary outcome of seizure freedom
secondary outcomes, including seizure reduction, quality of life and cognitive outcome
an attempt to obtain data on pharmaco-resistance
the possibility of including all children with specific epilepsy syndromes for consideration in the trial.
Source guidance details
- Comes from guidance
- Epilepsies: diagnosis and management
- Date issued
- January 2012
|Is this a recommendation for the use of a technology only in the context of research?||No|
|Is it a recommendation that suggests collection of data or the establishment of a register?||No|