- Recommendation ID
- Epilepsy syndromes:- What are the initial and add-on anti-epileptic drugs (AEDs) of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?
- Any explanatory notes
- Why this is important:- Despite the need to diagnose individual epilepsy syndromes, there is little evidence on the most appropriate initial or add-on anti-epileptic drugs (AEDs) in the treatment of the rarer epilepsies.
The research should include:
- multicentre randomised controlled comparative trials with centralised national data collection
- the ketogenic diet as one of the randomised treatments
- primary outcome of seizure freedom
- secondary outcomes, including seizure reduction, quality of life and cognitive outcome
- an attempt to obtain data on pharmaco-resistance
- the possibility of including all children with specific epilepsy syndromes for consideration in the trial.
Source guidance details
- Comes from guidance
- Epilepsies: diagnosis and management
- Date issued
- January 2012
|Is this a recommendation for the use of a technology only in the context of research?||No|
|Is it a recommendation that suggests collection of data or the establishment of a register?||No|