- Recommendation ID
Optimal dosage of intravenous insulin for managing diabetic ketoacidosis in children and young people:- What is the optimal dosage of intravenous insulin for managing diabetic ketoacidosis (DKA) in children and young people?
- Any explanatory notes
Why this is important:- The evidence reviewed for the guideline did not allow evaluation of the comparative effectiveness and safety of specific dosages of intravenous insulin, such as 0.025, 0.05 and 0.1 units/kg/hour. The only relevant studies conducted to date have been small retrospective cohort studies with fewer than 100 participants. A large, multi-centre randomised controlled trial is needed to undertake a comparative study of different dosages. This is because DKA is relatively uncommon and cerebral oedema (a potential adverse consequence of DKA) is rare, and there is a concern that larger dosages are associated with an increased risk of cerebral oedema. Important outcomes include rate of DKA resolution, incidence of hypoglycaemia and incidence of cerebral oedema.
Source guidance details
- Comes from guidance
- Diabetes (type 1 and type 2) in children and young people: diagnosis and management
- Date issued
- August 2015
|Is this a recommendation for the use of a technology only in the context of research?||No|
|Is it a recommendation that suggests collection of data or the establishment of a register?||No|