To diagnose FH in relatives of an index individual, the gender- and age-specific criteria for LDL-C concentration in appendix E of the NICE guideline should be used. The Simon Broome LDL-C criteria for index individuals should not be used because this will result in under diagnosis. Do not do recommendation August 2017
Levetiracetam is not cost effective at June 2011 unit costs. Offerlevetiracetam, oxcarbazepine or sodium valproate (provided the acquisitioncost of levetiracetam falls to at least 50% of June 2011 value documented inthe National Health Service Drug Tariff for England and Wales) if carbamazepine and lamotrigine are unsuitable or not tolerated. Do not do recommendation May 2017
Do not modify the renin angiotensin system antagonist dose if the change in eGFR is less than 25% or the change in serum creatinine is less than 30%. Do not do recommendation May 2017
Pirfenidone is recommended as an option for treating idiopathic pulmonary fibrosis only if:- the person has a forced vital capacity (FVC) between 50% and 80% predicted and- the manufacturer provides pirfenidone with the discount agreed in the patient access scheme.Treatment with pirfenidone that is recommended as above should be discontinued if there is evidence of disease progression (a decline in per cent predicted FVC of 10% or more within any 12 month period). Do not do recommendation May 2017
Calcium antagonists for aneurysmal subarachnoid haemorrhage Cochrane Topic April 2017 Very Low
Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children Cochrane Topic April 2017 Very Low
Bariatric surgery for non-alcoholic steatohepatitis in obese patients Cochrane Topic April 2017 Very High
Mechanical bowel preparation for elective colorectal surgery Cochrane Topic April 2017 Very Low
High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer Cochrane Topic February 2017 Exclude
Antibiotics for acute laryngitis in adults Cochrane Topic January 2017 Exclude