It can be difficult for prescribers to keep abreast of the large volume of relevant guidance and research. They must identify important new information and what is out of date among what they already know. This initiative aims to make this process easier by identifying relevant evidence and changes to practice, and then changing behaviours through peer discussions. These peer reviews allow time to discuss the evidence base behind the guidance, allowing concerns and questions to be raised and answered. The aim of medicines optimisation peer reviews is to influence prescribers to ensure evidence-based, safe, cost-effective prescribing. This improves clinical outcomes for patients, reduces variation between localities, improves alignment with NICE guidance and improves performance against relevant indicators.