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Indoor air quality at home (NG149)

This guideline covers indoor air quality in residential buildings. It aims to raise awareness of the importance of good air quality in people's homes and how to achieve this.

NICE guideline Published January 2020

Supporting adult carers (NG150)

This guideline covers support for adults (aged 18 and over) who provide unpaid care for anyone aged 16 or over with health or social care needs. It aims to improve the lives of carers by helping health and social care practitioners identify people who are caring for someone and give them the right information and support. It covers carers’ assessments, practical, emotional and social support and training, and support for carers providing end of life care.

NICE guideline Published January 2020

Colorectal cancer (NG151)

This guideline covers managing colorectal (bowel) cancer in people aged 18 and over. It aims to improve quality of life and survival for adults with colorectal cancer through management of local disease and management of secondary tumours (metastatic disease).

NICE guideline Published January 2020

Leg ulcer infection: antimicrobial prescribing (NG152)

This guideline sets out an antimicrobial prescribing strategy for adults with leg ulcer infection. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published February 2020

Workplace health: long-term sickness absence and capability to work (NG146)

This guideline covers how to help people return to work after long-term sickness absence, reduce recurring sickness absence, and help prevent people moving from short-term to long-term sickness absence.

NICE guideline Published November 2019

Menopause: diagnosis and management (NG23)

This guideline covers the diagnosis and management of menopause, including in women who have premature ovarian insufficiency. The guideline aims to improve the consistency of support and information provided to women in menopause.

NICE guideline Published November 2015 Last updated December 2019

Acute kidney injury: prevention, detection and management (NG148)

This guideline covers preventing, detecting and managing acute kidney injury in children, young people and adults. It aims to improve assessment and detection by non-specialists, and specifies when people should be referred to specialist services. This will improve early recognition and treatment, and reduce the risk of complications in people with acute kidney injury.

NICE guideline Published December 2019

Diverticular disease: diagnosis and management (NG147)

This guideline covers the diagnosis and management of diverticular disease in people aged 18 years and over. It aims to improve diagnosis and care and help people get timely information and advice, including advice about symptoms and when to seek help.

NICE guideline Published November 2019

Asthma: diagnosis, monitoring and chronic asthma management (NG80)

This guideline covers diagnosing, monitoring and managing asthma in adults, young people and children. It aims to improve the accuracy of diagnosis, help people to control their asthma and reduce the risk of asthma attacks. It does not cover managing severe asthma or acute asthma attacks.

NICE guideline Published November 2017 Last updated February 2020

Antenatal and postnatal mental health: clinical management and service guidance (CG192)

This guideline covers recognising, assessing and treating mental health problems in women who are planning to have a baby, are pregnant, or have had a baby or been pregnant in the past year. It covers depression, anxiety disorders, eating disorders, drug- and alcohol-use disorders and severe mental illness (such as psychosis, bipolar disorder and schizophrenia). It promotes early detection and good management of mental health problems to improve women’s quality of life during pregnancy and in the year after giving birth.

Clinical guideline Published December 2014 Last updated February 2020

Bipolar disorder: assessment and management (CG185)

This guideline covers recognising, assessing and treating bipolar disorder (formerly known as manic depression) in children, young people and adults. The recommendations apply to bipolar I, bipolar II, mixed affective and rapid cycling disorders. It aims to improve access to treatment and quality of life in people with bipolar disorder.

Clinical guideline Published September 2014 Last updated February 2020

Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer (CG164)

This guideline covers care for people with a family history of breast, ovarian or another related (prostate or pancreatic) cancer. It aims to improve the long-term health of these families by describing strategies to reduce the risk of and promote early detection of breast cancer (including genetic testing and mammography). It also includes advice on treatments (tamoxifen, raloxifene) and surgery (mastectomy).

Clinical guideline Published June 2013 Last updated November 2019

Epilepsies: diagnosis and management (CG137)

The guideline covers diagnosing, treating and managing epilepsy and seizures in children, young people and adults in primary and secondary care. It offers best practice advice on managing epilepsy to improve health outcomes so that people with epilepsy can fully participate in daily life.

Clinical guideline Published January 2012 Last updated February 2020

Thyroid disease: assessment and management (NG145)

This guideline covers investigating all suspected thyroid disease and managing primary thyroid disease (related to the thyroid rather than the pituitary gland). It does not cover managing thyroid cancer or thyroid disease in pregnancy. It aims to improve quality of life by making recommendations on diagnosis, treatment, long-term care and support.

NICE guideline Published November 2019

Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure (TA617)

Evidence-based recommendations on lusutrombopag (Mulpleo) for severe thrombocytopenia in adults with chronic liver disease needing a planned invasive procedure

Technology appraisal guidance Published January 2020

Atezolizumab with carboplatin and nab-paclitaxel for untreated advanced non-squamous non-small-cell lung cancer (terminated appraisal) (TA618)

NICE is unable to make a recommendation about the use in the NHS of atezolizumab (Tecentriq) with carboplatin and nab-paclitaxel for untreated advanced NSCLC

Technology appraisal guidance Published January 2020

Osimertinib for untreated EGFR mutation-positive non-small-cell lung cancer (TA621)

Evidence-based recommendations on osimertinib (Tagrisso) for untreated locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer (NSCLC)

Technology appraisal guidance Published January 2020

Patiromer for treating hyperkalaemia (TA623)

Evidence based recommendations on patiromer (Veltassa) for treating hyperkalaemia in adults

Technology appraisal guidance Published February 2020

Cladribine for treating relapsing–remitting multiple sclerosis (TA616)

Evidence-based recommendations on cladribine (Mavenclad) for relapsing–remitting multiple sclerosis (RRMS) in adults

Technology appraisal guidance Published December 2019

Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome (TA615)

Evidence-based recommendations on cannabidiol (Epidyolex) with clobazam for seizures associated with Lennox–Gastaut syndrome in people aged 2 years and older

Technology appraisal guidance Published December 2019

Cannabidiol with clobazam for treating seizures associated with Dravet syndrome (TA614)

Evidence-based recommendations on cannabidiol (Epidyolex) with clobazam for seizures associated with Dravet syndrome (DS) in people aged 2 years and older

Technology appraisal guidance Published December 2019

Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema in phakic eyes after an inadequate response to previous therapy (TA613)

Evidence-based recommendations on fluocinolone acetonide intravitreal implant (Iluvien) for chronic diabetic macular oedema that has inadequately responded to

Technology appraisal guidance Published November 2019

Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab (TA612)

Evidence-based recommendations on neratinib (Nerlynx) for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer

Technology appraisal guidance Published November 2019

Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2 (HST12)

Evidence-based recommendations on cerliponase alfa (Brineura) for treating neuronal ceroid lipofuscinosis type 2 in children

Highly specialised technologies guidance Published November 2019

Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer (TA619)

Evidence-based recommendations on palbociclib (Ibrance) with fulvestrant for hormone receptor-positive, HER2-negative locally advanced/metastatic breast cancer

Technology appraisal guidance Published January 2020

Olaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer (TA620)

Evidence-based recommendations on olaparib (Lynparza) for relapsed platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer in adults with a

Technology appraisal guidance Published January 2020

Sotagliflozin with insulin for treating type 1 diabetes (TA622)

Evidence-based recommendations on sotagliflozin with insulin for treating type 1 diabetes in adults with a body mass index (BMI) of at least 27 kg/m2

Technology appraisal guidance Published February 2020

Dapagliflozin with insulin for treating type 1 diabetes (TA597)

Evidence-based recommendations on dapagliflozin (Forxiga) with insulin for treating type 1 diabetes not controlled by insulin therapy alone in adults with a

Technology appraisal guidance Published August 2019 Last updated February 2020

Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis (TA624)

Evidence-based recommendations on peginterferon beta-1a (Plegridy) for treating relapsing–remitting multiple sclerosis in adults

Technology appraisal guidance Published February 2020

gammaCore for cluster headache (MTG46)

Evidence-based recommendations on gammaCore for cluster headache

Medical technologies guidance Published December 2019

Episcissors-60 for mediolateral episiotomy (MTG47)

Evidence-based recommendations on Episcissors-60 for mediolateral episiotomy

Medical technologies guidance Published February 2020

Balloon dilation for chronic eustachian tube dysfunction (IPG665)

Evidence-based recommendations on balloon dilation for chronic eustachian tube dysfunction in adults and children

Interventional procedures guidance Published December 2019

Irreversible electroporation for primary liver cancer (IPG664)

Evidence-based recommendations on irreversible electroporation for primary liver cancer in adults

Interventional procedures guidance Published November 2019

Reducing the risk of transmission of Creutzfeldt–Jakob disease (CJD) from surgical instruments used for interventional procedures on high-risk tissues (IPG666)

Evidence-based recommendations on reducing the risk of Creutzfeldt–Jakob disease (CJD) transmission from surgical instruments used for interventional procedures

Interventional procedures guidance Published January 2020

Fetoscopic prenatal repair for open neural tube defects in the fetus (IPG667)

Evidence-based recommendations on fetoscopic prenatal repair of open neural tube defects in the fetus

Interventional procedures guidance Published January 2020

Open prenatal repair for open neural tube defects in the fetus (IPG668)

Evidence-based recommendations on open prenatal repair of open neural tube defects in the fetus

Interventional procedures guidance Published January 2020

Virtual Touch Quantification to diagnose and monitor liver fibrosis in chronic hepatitis B and C (MTG27)

Evidence-based recommendations on Virtual Touch Quantification for diagnosing and monitoring liver fibrosis in chronic Hepatitis B and C

Medical technologies guidance Published September 2015 Last updated January 2020

SepsiTest assay for rapidly identifying bloodstream bacteria and fungi (DG20)

Evidence-based recommendations on the SepsiTest assay for rapidly identifying bloodstream bacteria and fungi

Diagnostics guidance Published February 2016 Last updated February 2020

What interventions are effective and cost effective at raising awareness of the health risks of damp and mould in the home?

Recommendation ID NG149/5 Question What interventions are effective and cost effective at raising awareness of the health risks of damp

Research recommendation Published February 2020

Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease in children under 5 presenting with fever lasting 5 days or more?

Recommendation ID NG143/8 Question Which signs and symptoms (or combinations of signs and symptoms) predict a diagnosis of Kawasaki disease

Research recommendation Published February 2020

What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD spray for children, young people and adults with spasticity? In particular, what is the impact of spasticity on improvements in quality of life?

Recommendation ID NG144/5 Question What is the clinical and cost effectiveness of cannabis-based medicinal products other than THC: CBD

Research recommendation Published February 2020

What is the effectiveness of personal health and social care budgets in supporting carers to return to work, education or training?

Recommendation ID NG150/2 Question What is the effectiveness of personal health and social care budgets in supporting carers to return to

Research recommendation Published February 2020

What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis, including timing of surgery (elective or emergency)?

Recommendation ID NG147/5 Question What are the clinically and cost-effective surgical approaches to managing complicated acute diverticulitis

Research recommendation Published February 2020

What training, support or interventions help to reduce caring-related accidents or incidents?

Recommendation ID NG150/3 Question What training, support or interventions help to reduce caring-related accidents or incidents? Any

Research recommendation Published February 2020

What are the risk factors for diverticulosis progressing to diverticular disease?

Recommendation ID NG147/6 Question What are the risk factors for diverticulosis progressing to diverticular disease? Any explanatory

Research recommendation Published February 2020

Can risk of contrast-induced acute kidney injury be stratified by eGFR thresholds?

Recommendation ID NG148/1 Question Can risk of contrast-induced acute kidney injury be stratified by eGFR thresholds? Any explanatory

Research recommendation Published February 2020

What is the effectiveness, cost effectiveness and acceptability of the whole family approach to carers' assessments?

Recommendation ID NG150/1 Question What is the effectiveness, cost effectiveness and acceptability of the whole family approach to carers'

Research recommendation Published February 2020

What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy compared to resection for people with metastatic colorectal cancer in the lung amenable to local treatment?

Recommendation ID NG151/1 Question What is the cost effectiveness and safety of non-surgical ablation and stereotactic body radiotherapy

Research recommendation Published February 2020