Updating results

Menopause: diagnosis and management (NG23)

This guideline covers the diagnosis and management of menopause, including in women who have premature ovarian insufficiency. The guideline aims to improve the consistency of support and information provided to women in menopause.

NICE guideline Published November 2015 Last updated December 2019

gammaCore for cluster headache (MTG46)

Evidence-based recommendations on gammaCore for cluster headache

Medical technologies guidance Published December 2019

Cerliponase alfa for treating neuronal ceroid lipofuscinosis type 2 (HST12)

Evidence-based recommendations on cerliponase alfa (Brineura) for treating neuronal ceroid lipofuscinosis type 2 (CLN2) in children

Highly specialised technologies guidance Published November 2019

Diverticular disease: diagnosis and management (NG147)

This guideline covers the diagnosis and management of diverticular disease in people aged 18 years and over. It aims to improve diagnosis and care and help people get timely information and advice, including advice about symptoms and when to seek help.

NICE guideline Published November 2019

Irreversible electroporation for primary liver cancer (IPG664)

Evidence-based recommendations on irreversible electroporation for primary liver cancer in adults

Interventional procedures guidance Published November 2019

Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab (TA612)

Evidence-based recommendations on neratinib (Nerlynx) for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer

Technology appraisal guidance Published November 2019

Fluocinolone acetonide intravitreal implant for treating chronic diabetic macular oedema in phakic eyes after an inadequate response to previous therapy (TA613)

Evidence-based recommendations on fluocinolone acetonide intravitreal implant (Iluvien) for chronic diabetic macular oedema that has inadequately responded to

Technology appraisal guidance Published November 2019

Workplace health: long-term sickness absence and capability to work (NG146)

This guideline covers how to help people return to work after long-term sickness absence, reduce recurring sickness absence, and help prevent people moving from short-term to long-term sickness absence.

NICE guideline Published November 2019

Thyroid disease: assessment and management (NG145)

This guideline covers investigating all suspected thyroid disease and managing primary thyroid disease (related to the thyroid rather than the pituitary gland). It does not cover managing thyroid cancer or thyroid disease in pregnancy. It aims to improve quality of life by making recommendations on diagnosis, treatment, long-term care and support.

NICE guideline Published November 2019

Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer (CG164)

This guideline covers care for people with a family history of breast, ovarian or another related (prostate or pancreatic) cancer. It aims to improve the long-term health of these families by describing strategies to reduce the risk of and promote early detection of breast cancer (including genetic testing and mammography). It also includes advice on treatments (tamoxifen, raloxifene) and surgery (mastectomy).

Clinical guideline Published June 2013 Last updated November 2019

When is it safe to stop contact casting in the treatment of acute Charcot arthropathy?

Recommendation ID NG19/12 Question When is it safe to stop contact casting in the treatment of acute Charcot arthropathy? Any explanatory

Research recommendation Published November 2019

Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy?

Recommendation ID NG19/11 Question Which risk stratification tools can be used to predict the likelihood of Charcot arthropathy? Any

Research recommendation Published November 2019

What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot ulcers?

Recommendation ID NG19/10 Question What is the clinical effectiveness of maggot debridement therapy in the debridement of diabetic foot

Research recommendation Published November 2019

What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot ulcers?

Recommendation ID NG19/9 Question What is the clinical effectiveness of negative pressure wound therapy in the treatment of diabetic foot

Research recommendation Published November 2019

Which of the electronic information-sharing systems perform best for the care of people approaching the end of their life?

Recommendation ID NG142/2 Question Which of the electronic information-sharing systems perform best for the care of people approaching the

Research recommendation Published November 2019

Does early review of service provision and referral to additional specialist palliative care services improve outcomes for adults with progressive non-cancer disease thought to be approaching the end of their life?

Recommendation ID NG142/1 Question Does early review of service provision and referral to additional specialist palliative care services

Research recommendation Published November 2019

What are the benefits of planned, regular community-based reviews compared with as-required review of non-cancer patients approaching the end of their life?

Recommendation ID NG142/3 Question What are the benefits of planned, regular community-based reviews compared with as-required review of

Research recommendation Published November 2019

What is the optimal way of discharging people approaching the end of their life from hospitals back to their place of residence?

Recommendation ID NG142/4 Question What is the optimal way of discharging people approaching the end of their life from hospitals back to

Research recommendation Published November 2019

Evidence on the safety and efficacy of midcarpal hemiarthroplasty for wrist arthritis is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG663/1 Question Evidence on the safety and efficacy of midcarpal hemiarthroplasty for wrist arthritis is inadequate

Research recommendation Published November 2019

How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis or gangrene) be reviewed?

Recommendation ID NG19/8 Question How often should people with diabetic foot problems (foot ulcers, soft tissue infections, osteomyelitis

Research recommendation Published November 2019

What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?

Recommendation ID CG71/6 Question What is the utility of routine cardiovascular evaluation for asymptomatic people with FH? Any explanatory

Research recommendation Published November 2019

What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants with frequent regurgitation associated with marked distress?

Recommendation ID NG1/2 Question What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants

Research recommendation Published November 2019

What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers who have taken AEDs during pregnancy?

Recommendation ID CG137/5 Question What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers

Research recommendation Published November 2019

What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Recommendation ID NG19/5 Question What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Research recommendation Published November 2019

What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): to reduce severe oesophagitis to control symptoms as maintenance therapy?

Recommendation ID CG184/3 Question What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los

Research recommendation Published November 2019

What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

Recommendation ID CG137/2 Question What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset

Research recommendation Published November 2019

What is the effectiveness of laparoscopic fundoplication compared with medical management in people with GORD that does not respond to optimal proton pump inhibitor (PPI) treatment?

Recommendation ID CG184/2 Question What is the effectiveness of laparoscopic fundoplication compared with medical management in people with

Research recommendation Published November 2019

What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?

Recommendation ID CG71/4 Question What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous

Research recommendation Published November 2019

What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children with FH?

Recommendation ID CG71/3 Question What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children

Research recommendation Published November 2019

What is the role of educational models and psycho-behavioural interventions in prevention of diabetic foot complications?

Recommendation ID NG19/3 Question What is the role of educational models and psycho-behavioural interventions in prevention of diabetic

Research recommendation Published November 2019

When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

Research recommendation Published November 2019

Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure control and resolution of the hypsarrhythmic EEG influence the long-term developmental and cognitive outcomes more than the underlying cause of the spasms?

Recommendation ID CG137/3 Question Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure

Research recommendation Published November 2019

In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

Research recommendation Published November 2019

When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

Research recommendation Published November 2019

What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H2 receptor antagonists (H2RAs) despite optimum primary care?

Recommendation ID CG184/5 Question What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in

Research recommendation Published November 2019

What are the symptoms of GORD in infants, children and young people with a neurodisability?

Recommendation ID NG1/1 Question What are the symptoms of GORD in infants, children and young people with a neurodisability? Any explanatory

Research recommendation Published November 2019

In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive of GORD, what patient characteristics, risk factors and predictors indicate when endoscopy is needed to exclude Barrett's oesophagus?

Recommendation ID CG184/1 Question In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive

Research recommendation Published November 2019

What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who are treated with statin therapy?

Recommendation ID CG71/2 Question What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who

Research recommendation Published November 2019

Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated with developing the disease and is such monitoring cost effective?

Recommendation ID NG19/1 Question Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated with

Research recommendation Published November 2019

What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum primary care, or for people whose symptoms return after surgery?

Recommendation ID CG184/4 Question What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum

Research recommendation Published November 2019

What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

Recommendation ID CG137/4 Question What is the most effective and safest AED to treat: established (usually lasting longer than 30

Research recommendation Published November 2019

What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary care case finding?

Recommendation ID CG71/1 Question What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary

Research recommendation Published November 2019

What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies

Recommendation ID CG71/5 Question What are the implications of FH for the safety of a mother during pregnancy and what are the risks of

Research recommendation Published November 2019

What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems?

Recommendation ID NG19/7 Question What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems

Research recommendation Published November 2019

What strategies may be useful in the prevention of Charcot arthropathy?

Recommendation ID NG19/4 Question What strategies may be useful in the prevention of Charcot arthropathy? Any explanatory notes(if

Research recommendation Published November 2019