Updating results

Urinary tract infections

Everything NICE has said on diagnosing, treating and managing urinary tract infections including lower (cystitis), upper (acute pyelonephritis) and recurrent UTIs in people with or without a catheter in an interactive flowchart

NICE Pathway Published August 2012 Last updated November 2019

Postnatal care

Everything NICE has said on the essential care that every woman and her baby should receive in the first 6–8 weeks after birth in an interactive flowchart

NICE Pathway Published May 2011 Last updated November 2019

What is the clinical and cost effectiveness of relaxation therapies for managing primary hypertension in adults in terms of reducing cardiovascular events and improving quality of life?

Recommendation ID NG136/5 Question What is the clinical and cost effectiveness of relaxation therapies for managing primary hypertension

Research recommendation Published November 2019

Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation?

Recommendation ID NG136/1 Question Which automated blood pressure monitors are suitable for people with hypertension and atrial fibrillation

Research recommendation Published November 2019

What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Recommendation ID NG136/3 Question What is the optimum blood pressure target for people aged over 80 with treated primary hypertension?

Research recommendation Published November 2019

Bronchiolitis in children

Everything NICE has said on diagnosing and managing bronchiolitis in children in an interactive flowchart

NICE Pathway Published June 2015 Last updated November 2019

ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for starting treatment?

Recommendation ID NG136/2 Question ion (with or without type 2 diabetes), what are the appropriate risk and blood pressure thresholds for

Research recommendation Published November 2019

Are there subgroups of people with hypertension who should start on dual therapy?

Recommendation ID NG136/4 Question Are there subgroups of people with hypertension who should start on dual therapy? Any explanatory

Research recommendation Published November 2019

Respiratory conditions

Everything NICE has said on respiratory conditions in an interactive flowchart

NICE Pathway Published June 2015 Last updated October 2019

Generalised anxiety disorder

Everything NICE has said on managing generalised anxiety disorder in adults in primary, secondary and community care in an interactive flowchart

NICE Pathway Published March 2012 Last updated October 2019

Pressure ulcers

Everything NICE has said on preventing and managing pressure ulcers in all age groups in primary care and community settings in an interactive flowchart

NICE Pathway Published January 2012 Last updated October 2019

Abortion care

Everything NICE has said on abortion care in an interactive flowchart.

NICE Pathway Published September 2019 Last updated October 2019

Ibrutinib with rituximab for treating Waldenstrom's macroglobulinaemia (terminated appraisal) (TA608)

NICE is unable to make a recommendation about the use in the NHS of ibrutinib (Imbruvica) with rituximab for treating Waldenstrom’s macroglobulinaemia in adults

Technology appraisal guidance Published October 2019

Ramucirumab for treating unresectable hepatocellular carcinoma after sorafenib (terminated appraisal) (TA609)

NICE is unable to make a recommendation about the use in the NHS of ramucirumab (Cyramza) for treating unresectable hepatocellular carcinoma after sorafenib

Technology appraisal guidance Published October 2019

Non-Hodgkin's lymphoma

Everything NICE has said on diagnosing and managing non-Hodgkin's lymphoma in adults and young people 16 years and older in an interactive flowchart

NICE Pathway Published July 2016 Last updated October 2019

Liver cancers

Everything NICE has said on liver and bile duct cancers in an interactive flowchart

NICE Pathway Published November 2013 Last updated October 2019

What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural activation compared with other psychological therapies in children aged 5 to 11 years and young people aged 12 to 18 years with mild or moderate to severe depression?

Recommendation ID NG134/5 Question What is the clinical and cost effectiveness, post treatment and at longer-term follow‑up, of behavioural

Research recommendation Published October 2019

What is the clinical utility of bone turnover markers in the diagnosis and management of primary hyperparathyroidism?

Recommendation ID NG132/1 Question What is the clinical utility of bone turnover markers in the diagnosis and management of primary...

Research recommendation Published October 2019

What is the prognostic value of different risk stratification methods for people with locally advanced prostate cancer?

Recommendation ID NG131/7 Question What is the prognostic value of different risk stratification methods for people with locally advanced

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate cancer?

Recommendation ID NG131/3 Question What is the most clinically and cost-effective pathway for diagnosing clinically significant prostate

Research recommendation Published October 2019

How effective are education-based alcohol prevention interventions (universal or targeted) for children and young people aged 11 to 25 with SEND in full-time education?

Recommendation ID NG135/5 Question How effective are education-based alcohol prevention interventions (universal or targeted) for children

Research recommendation Published October 2019

What is the most clinically and cost-effective pathway for excluding the clinically significant progression of cancer in people with low- to intermediate-risk prostate cancer?

Recommendation ID NG131/4 Question What is the most clinically and cost-effective pathway for excluding the clinically significant progression

Research recommendation Published October 2019

At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm birth be started and stopped?

Recommendation ID NG25/7 Question At what gestation should treatment with prophylactic vaginal progesterone for the prevention of preterm

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of 25 mm or less), but do not have other risk factors for preterm birth?

Recommendation ID NG25/6 Question Does progesterone reduce the risk of preterm birth in women who have a short cervix (cervical length of

Research recommendation Published October 2019

Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but do not have a short cervix (cervical length of more than 25 mm)?

Recommendation ID NG25/5 Question Does progesterone reduce the risk of preterm birth in women who have risk factors for preterm birth, but

Research recommendation Published October 2019

What is the best and most cost-effective management strategy for people whose first surgery for primary hyperparathyroidism is not successful?

Recommendation ID NG132/2 Question What is the best and most cost-effective management strategy for people whose first surgery for primary

Research recommendation Published October 2019

What are the optimal management strategies for primary hyperparathyroidism during pregnancy?

Recommendation ID NG132/4 Question What are the optimal management strategies for primary hyperparathyroidism during pregnancy? Any

Research recommendation Published October 2019

What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological therapies in children aged 5 to 11 years with mild or moderate to severe depression?

Recommendation ID NG134/1 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of psychological

Research recommendation Published October 2019

What methods and techniques help secondary schools and providers to effectively engage with parents and carers as part of a whole-school approach to promote and support alcohol education?

Recommendation ID NG135/6 Question What methods and techniques help secondary schools and providers to effectively engage with parents and

Research recommendation Published October 2019

The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide when used in people with multiple myeloma who have received two or more prior therapies.

Recommendation ID TA171/1 Question The Committee considered that rigorous data collection is needed on the life-extending benefits of lenalidomide

Research recommendation Published October 2019

What are the long-term outcomes of different management strategies for primary hyperparathyroidism? Which strategies are most cost effective?

Recommendation ID NG132/3 Question What are the long-term outcomes of different management strategies for primary hyperparathyroidism? Which

Research recommendation Published October 2019

What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term follow‑up?

Recommendation ID NG131/5 Question What is the natural history of people with a Likert score on MRI of less than 3 without biopsy at long-term

Research recommendation Published October 2019

How effective and cost effective are education-based alcohol interventions targeted at children and young people aged 11 to 25 with SEND who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/4 Question How effective and cost effective are education-based alcohol interventions targeted at children and young

Research recommendation Published October 2019

How effective and cost effective are individual, compared with group, education-based interventions for children and young people aged 11 to 18 in full-time education who are thought to be vulnerable to alcohol misuse?

Recommendation ID NG135/2 Question How effective and cost effective are individual, compared with group, education-based interventions for

Research recommendation Published October 2019

What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate in the induction of remission in mild-to-moderate ulcerative colitis unresponsive to aminosalicylates?

Recommendation ID NG130/2 Question What is the effectiveness of oral tacrolimus and systemic (intramuscular/subcutaneous/oral) methotrexate

Research recommendation Published October 2019

What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition to aminosalicylates compared with each other and with aminosalicylate monotherapy for the induction of remission for people with mild-to-moderate ulcerative colitis?

Recommendation ID NG130/3 Question What is the clinical and cost effectiveness of prednisolone, budesonide, and beclometasone in addition

Research recommendation Published October 2019

How effective and cost effective are universal, education-based alcohol interventions for children and young people aged 11 to 25 with SEND?

Recommendation ID NG135/3 Question How effective and cost effective are universal, education-based alcohol interventions for children and

Research recommendation Published October 2019

What components of alcohol education delivery contribute to its effectiveness for children and young people aged 11 to 18 in full-time education, and those with special educational needs and disabilities (SEND) up to the age of 25?

Recommendation ID NG135/1 Question What components of alcohol education delivery contribute to its effectiveness for children and young

Research recommendation Published October 2019

The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices in primary care for people with signs or symptoms of atrial fibrillation, and an irregular pulse, increases the number of people with atrial fibrillation (including paroxysmal) detected, ompared with current practice (that is, a 12‑lead ECG done later). The committee considered the feasibility of collecting data to see if using the lead‑I ECG devices increased the detection of atrial fibrillation that would be missed if only 12‑lead ECGs done later were available. It noted that even if a lead‑I ECG is used and atrial fibrillation is detected, a subsequent 12‑lead ECG would still be done to check for structural cardiac abnormalities and inform further management decisions. The committee concluded that practices using lead‑I ECG devices could determine the number of additional cases of atrial fibrillation detected by the devices. This can be done by identifying people with a confirmed positive lead‑I ECG for atrial fibrillation who subsequently had a 12‑lead ECG that was negative because the atrial fibrillation had stopped. The committee also considered that data collected on the time between the initial lead‑I ECG and the subsequent 12‑lead ECG would be useful.

Recommendation ID DG35/1 Question The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices

Research recommendation Published October 2019

What are the benefits, risk and cost effectiveness of enteral nutrition in maintaining remission in the post-surgical period of Crohn's disease?

Recommendation ID NG129/1 Question What are the benefits, risk and cost effectiveness of enteral nutrition in maintaining remission in the

Research recommendation Published October 2019