Updating results

The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG655 Question The evidence on cardiac contractility modulation device implantation for heart failure raises no major

Research recommendation Published November 2019

Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon technique) for locally advanced rectal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG659/1 Question Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon

Research recommendation Published November 2019

Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG660/1 Question Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in

Research recommendation Published November 2019

Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research.

Recommendation ID IPG661/1 Question Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate

Research recommendation Published November 2019

Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe emphysema is inadequate in quantity and quality. Therefore the procedure should only be used in the context of research.

Recommendation ID IPG652/1 Question Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe

Research recommendation Published November 2019

Leukomed Sorbact for preventing surgical site infection (MIB197)

Advice on the use of Leukomed Sorbact for preventing surgical site infection (SSI) to aid local decision making

Medtech innovation briefing Published November 2019

Melanoma

Everything NICE has said assessing and managing melanoma in an interactive flowchart

NICE Pathway Published July 2015 Last updated November 2019

Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer (TA611)

Evidence-based recommendations on rucaparib (Rubraca) for relapsed platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer that has responded to

Technology appraisal guidance Published November 2019

Pentosan polysulfate sodium for treating bladder pain syndrome (TA610)

Evidence-based recommendations on pentosan polysulfate sodium (Elmiron) for bladder pain syndrome in adults

Technology appraisal guidance Published November 2019

Rapid tests for group A streptococcal infections in people with a sore throat (DG38)

Evidence-based recommendations on rapid tests for group A streptococcal (strep A) infections in people aged 5 and over with a sore throat

Diagnostics guidance Published November 2019

Point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrast (DG37)

Evidence-based recommendations on point-of-care creatinine devices to assess kidney function before CT imaging with intravenous contrast

Diagnostics guidance Published November 2019

Ovarian cancer

Everything NICE has said on recognising and managing ovarian cancer in an interactive flowchart

NICE Pathway Published February 2012 Last updated November 2019

Urogenital conditions

Everything NICE has said on urogenital conditions in an interactive flowchart

NICE Pathway Published June 2015 Last updated November 2019

Excess winter deaths and illnesses associated with cold homes

Everything NICE has said on reducing the risk of excess winter deaths and illness associated with cold homes in an interactive flowchart

NICE Pathway Published March 2015 Last updated November 2019

Self-limiting respiratory tract and ear infections – antibiotic prescribing

Everything NICE has said on antibiotic prescribing for self-limiting respiratory tract and ear infections in primary care in an interactive flowchart

NICE Pathway Published August 2012 Last updated November 2019

Acute kidney injury

Everything NICE has said on preventing, detecting and managing acute kidney injury in an interactive flowchart

NICE Pathway Published August 2013 Last updated November 2019

Cannabis-based medicinal products

Everything NICE has said on cannabis-based medicinal products in an interactive flowchart.

NICE Pathway Published November 2019

Multiple sclerosis

Everything NICE has said on multiple sclerosis in an interactive flowchart

NICE Pathway Published October 2014 Last updated November 2019

Multiple sclerosis in adults: management (CG186)

This guideline covers diagnosing and managing multiple sclerosis in people aged 18 and over. It aims to improve the quality of life for adults with multiple sclerosis by promoting symptom management, comprehensive reviews and effective relapse treatment.

Clinical guideline Published October 2014 Last updated November 2019

Cannabis-based medicinal products (NG144)

This guideline covers prescribing of cannabis-based medicinal products for people with intractable nausea and vomiting, chronic pain, spasticity and severe treatment-resistant epilepsy.

NICE guideline Published November 2019

What is the optimal regimen for general anaesthesia for women having surgical abortion?

Recommendation ID NG140/7 Question What is the optimal regimen for general anaesthesia for women having surgical abortion? Any explanatory

Research recommendation Published November 2019

What local anaesthetic techniques are most effective for women having surgical abortion?

Recommendation ID NG140/5 Question What local anaesthetic techniques are most effective for women having surgical abortion? Any explanatory

Research recommendation Published November 2019

What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Recommendation ID NG140/1 Question What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Research recommendation Published November 2019

Should women having a surgical abortion up to and including 10+0 weeks' gestation have anti-D prophylaxis if they are RhD (or D) negative?

Recommendation ID NG140/3 Question Should women having a surgical abortion up to and including 10+0 weeks' gestation have anti-D prophylaxis

Research recommendation Published November 2019

What are the most effective and acceptable methods of cervical priming before dilatation and evacuation after 16+0 weeks' gestation?

Recommendation ID NG140/2 Question What are the most effective and acceptable methods of cervical priming before dilatation and evacuation

Research recommendation Published November 2019

Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?

Recommendation ID NG33/2 Question Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing

Research recommendation Published November 2019

Which people with extreme hypertension (220/120 mmHg or higher) or emergency symptoms should be referred for same-day hospital specialist assessment?

Recommendation ID NG136/6 Question Which people with extreme hypertension (220/120 mmHg or higher) or emergency symptoms should be referred

Research recommendation Published November 2019

What is the most accurate prenatal screening marker for TAPS, including middle cerebral artery peak systolic velocity (MCA‑PSV)?

Recommendation ID NG137/1 Question What is the most accurate prenatal screening marker for TAPS, including middle cerebral artery peak systolic

Research recommendation Published November 2019

For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Recommendation ID NG33/3 Question For isoniazid-resistant TB, what is the most effective regimen for reducing mortality andmorbidity?

Research recommendation Published November 2019

For people with active, drug susceptible TB who experience treatment interruptions because of adverse events, particularly hepatotoxicity, what approach to re-establishing treatment is mosteffective in reducing mortality and morbidity?

Recommendation ID NG33/5 Question For people with active, drug susceptible TB who experience treatment interruptions because of adverse

Research recommendation Published November 2019

In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based use of rapid nucleic acid amplification tests?

Recommendation ID NG33/1 Question In people with suspected TB, what is the relative clinical and cost effectiveness of universal andrisk-based

Research recommendation Published November 2019

What effects does isolation have on the quality of life of people being treated for TB?

Recommendation ID NG33/4 Question What effects does isolation have on the quality of life of people being treated for TB? Any explanatory

Research recommendation Published November 2019

What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are having medical abortion after 23+6 weeks' gestation, particularly for those who have had a previous caesarean section or uterine surgery?

Recommendation ID NG140/6 Question What is the effectiveness and safety of regimens using mifepristone and misoprostol for women who are

Research recommendation Published November 2019

For women who are having medical abortion between 10+1 and 12+0 weeks, what is the efficacy and acceptability of expulsion at home compared with expulsion in a clinical setting?

Recommendation ID NG140/4 Question For women who are having medical abortion between 10+1 and 12+0 weeks, what is the efficacy and acceptability

Research recommendation Published November 2019

Skin conditions

Everything NICE has said on managing skin conditions and skin damage in an interactive flowchart

NICE Pathway Published March 2015 Last updated November 2019

Fever in under 5s: assessment and initial management (NG143)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care.

NICE guideline Published November 2019

Bacterial meningitis and meningococcal septicaemia in under 16s

Everything NICE has said on managing bacterial meningitis and meningococcal septicaemia in children and young people in an interactive flowchart

NICE Pathway Published July 2012 Last updated November 2019

Maternal and child nutrition

Everything NICE has said on maternal and child nutrition in an interactive flowchart

NICE Pathway Published November 2012 Last updated November 2019

Social and emotional wellbeing for children and young people

Everything NICE has said on supporting the social and emotional wellbeing of children and young people in an interactive flowchart

NICE Pathway Published December 2011 Last updated November 2019

Antenatal and postnatal mental health

Everything NICE has said on antenatal and postnatal mental health in an interactive flowchart

NICE Pathway Published November 2011 Last updated November 2019