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Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided epidural injections for people with acute sciatica?

Recommendation ID NG59/4 Question Epidurals:- What is the clinical and cost effectiveness of image-guided compared with non-image-guided

Research recommendation Published February 2017

Costing tool:- Which elements of health, social care or other support services work best at a local level and provide the best 'value for money' to address the needs of young people and adults with coexisting severe mental illness and substance misuse?

Recommendation ID NG58/3 Question Costing tool:- Which elements of health, social care or other support services work best at a local level

Research recommendation Published February 2017

Further research is recommended on resource use and clinical effects associated with using the xTAG Gastrointestinal Pathogen Panel, the FilmArray GI Panel and the Faecal Pathogens B assay.

Recommendation ID DG26/1 Question Further research is recommended on resource use and clinical effects associated with using the xTAG Gastrointestinal

Research recommendation Published February 2017

Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such as web-based interventions, online self-assessment or targeted new media, for drug misuse prevention among groups at risk in the UK?

Recommendation ID NG64/5 Question Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such

Research recommendation Published May 2017

Chronic conditions:- What is the prevalence of disease in the UK prison population?

Recommendation ID NG57/2 Question Chronic conditions:- What is the prevalence of disease in the UK prison population? Any explanatory

Research recommendation Published November 2017

Barriers and facilitators:- What are the barriers and facilitators for young people and adults with coexisting severe mental illness and substance misuse to obtain an optimal service (including optimal time frame for delivering interventions) to meet their needs and enable their recovery?

Recommendation ID NG58/4 Question Barriers and facilitators:- What are the barriers and facilitators for young people and adults with coexisting

Research recommendation Published February 2017

Care pathway:- In the UK, what is the optimal care pathway for young people and adults with coexisting severe mental illness and substance misuse?

Recommendation ID NG58/5 Question Care pathway:- In the UK, what is the optimal care pathway for young people and adults with coexisting

Research recommendation Published February 2017

Further research should report details of patient selection, nodule size and position, and whether the nodule is cystic.

Recommendation ID IPG643/1 Question Further research should report details of patient selection, nodule size and position, and whether the

Research recommendation Published March 2019

Further research should include details of patient selection, durability and the incidence of complications. Outcomes should be published.

Recommendation ID IPG642/1 Question Further research should include details of patient selection, durability and the incidence of complications

Research recommendation Published March 2019

Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied to the upper limb in adults with cerebral palsy to improve or maintain posture or function?

Recommendation ID NG119/5 Question Splinting to improve or maintain posture or function:- What is the optimum regimen for splints applied

Research recommendation Published March 2019

Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically and cost effective route of administration for NSAIDs in the management of acute pain thought to be due to renal or ureteric stones?

Recommendation ID NG118/5 Question Non-steroidal anti-inflammatory drugs (NSAIDs) – route of administration:- What is the most clinically

Research recommendation Published March 2019

Alpha blockers and ureteroscopy- What is the clinical and cost effectiveness of tamsulosin as an adjunct to ureteroscopy?

Recommendation ID NG118/2 Question Alpha blockers and ureteroscopy- What is the clinical and cost effectiveness of tamsulosin as an adjunct

Research recommendation Published March 2019

Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness of selective dorsal rhizotomy compared with intrathecal baclofen to reduce spasticity in adults with cerebral palsy?

Recommendation ID NG119/2 Question Selective dorsal rhizotomy treatment to reduce spasticity:- What is the clinical and cost effectiveness

Research recommendation Published March 2019

Metabolic assessment:- What is the clinical and cost effectiveness of full metabolic assessment compared with standard advice alone, in people with recurrent calcium oxalate stones?

Recommendation ID NG118/1 Question Metabolic assessment:- What is the clinical and cost effectiveness of full metabolic assessment compared

Research recommendation Published March 2019

Frequency of follow-up imaging:- What is the clinical and cost effectiveness of 6-monthly imaging for 3 years for people with recurrent calcium renal or ureteric stones?

Recommendation ID NG118/4 Question Frequency of follow-up imaging:- What is the clinical and cost effectiveness of 6-monthly imaging for

Research recommendation Published March 2019

The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore further research is recommended. Any research should measure the effect of treatment using preference-based measures (such as use of the EQ-5D questionnaire).

Recommendation ID TA556/2 Question The health-related quality-of-life evidence of patients with perianal fistulas is also lacking, therefore

Research recommendation Published March 2019

Further research on platelet-rich plasma injections for knee osteoarthritis should be in the form of randomised controlled trials with medium- to long-term follow-up, including validated measures of knee function and patient-reported outcomes.

Recommendation ID IPG637/1 Question Further research on platelet-rich plasma injections for knee osteoarthritis should be in the form of

Research recommendation Published February 2019

Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation should report the exact method of perfusion used (such ashypothermic or normothermic), graft survival and the use of marginal grafts.

Recommendation ID IPG636/1 Question Further research on ex-situ machine perfusion for extracorporeal preservation of livers for transplantation

Research recommendation Published February 2019

Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder cancer should include randomised controlled trials compared withstandard care, which should report details of patient selection.

Recommendation ID IPG638/1 Question Further research on electrically stimulated intravesical chemotherapy for nonmuscle-invasive bladder

Research recommendation Published February 2019

Detection and management of respiratory disorders in primary and community care:- Can detection and management of respiratory disorders in adults with cerebral palsy be improved in primary and community care?

Recommendation ID NG119/3 Question Detection and management of respiratory disorders in primary and community care:- Can detection and management

Research recommendation Published March 2019

Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost effective in the management of respiratory symptoms in adults with cerebral palsy with significant respiratory comorbidity?

Recommendation ID NG119/4 Question Prophylactic antibiotics for respiratory disorders:- Are prophylactic antibiotics clinically and cost

Research recommendation Published March 2019

Augmentative and alternative communication systems:- Are augmentative and alternative communication systems clinically and cost effective in promoting  communication for adults with cerebral palsy who have communication difficulties?

Recommendation ID NG119/6 Question Augmentative and alternative communication systems:- Are augmentative and alternative communication systems

Research recommendation Published March 2019

Subsequent health assessment:- When should subsequent health assessments be carried out in prison for people serving long-term sentences?

Recommendation ID NG57/1 Question Subsequent health assessment:- When should subsequent health assessments be carried out in prison for

Research recommendation Published February 2017

Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option?

Recommendation ID NG59/5 Question Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option? Any

Research recommendation Published February 2017

Pharmacological management of peripheral spondyloarthritis:- What is the comparative effectiveness and cost effectiveness of standard DMARDs for managing peripheral spondyloarthritis, and is this effectiveness affected by differences in dose escalation protocols?

Recommendation ID NG65/4 Question Pharmacological management of peripheral spondyloarthritis:- What is the comparative effectiveness and

Research recommendation Published May 2017

Behavioural strategies and programmes:- What is the feasibility and effectiveness of specific behavioural strategies and programmes to reduce inappropriate antimicrobial demand and use and to prevent infections occurring and spreading?

Recommendation ID NG63/2 Question Behavioural strategies and programmes:- What is the feasibility and effectiveness of specific behavioural

Research recommendation Published February 2017

Structured clinical management interventions in probation service providers:- What is the effectiveness of structured clinical (case) management in improving mental health outcomes using interventions within probation service providers?

Recommendation ID NG66/2 Question Structured clinical management interventions in probation service providers:- What is the effectiveness

Research recommendation Published May 2017

Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different settings, for different types of tests, using different strategies (for example opt-in or opt-out approaches) and in areas and groups with different background prevalence?

Recommendation ID NG60/5 Question Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different

Research recommendation Published February 2017

Prevalence of mental health problems:- What is the prevalence of mental health problems and associated social problems for those in contact with the criminal justice system?

Recommendation ID NG66/5 Question Prevalence of mental health problems:- What is the prevalence of mental health problems and associated

Research recommendation Published May 2017

Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective are interventions using indicator condition-targeted testing compared with other testing strategies?

Recommendation ID NG60/4 Question Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective

Research recommendation Published February 2017

Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child or young person with a life-limiting condition is likely to die within hours or days?

Recommendation ID NG61/5 Question Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child

Research recommendation Published February 2017

Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What is the prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy?

Recommendation ID NG62/5 Question Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What

Research recommendation Published February 2017

Pharmacological therapies:- What is the clinical and cost effectiveness of codeine with and without paracetamol for the acute management of low back pain?

Recommendation ID NG59/2 Question Pharmacological therapies:- What is the clinical and cost effectiveness of codeine with and without paracetamol

Research recommendation Published February 2017

Identifying current practice and provision:- What drug misuse prevention activities are currently used in the UK for groups at risk of drug misuse?

Recommendation ID NG64/2 Question Identifying current practice and provision:- What drug misuse prevention activities are currently used

Research recommendation Published May 2017

Optimising nutritional status in children with cerebral palsy:- What is the clinical and cost effectiveness of early interventions for optimising protein, energy and micronutrient nutritional status in children with cerebral palsy?

Recommendation ID NG62/1 Question Optimising nutritional status in children with cerebral palsy:- What is the clinical and cost effectiveness

Research recommendation Published February 2017

Managing breakthrough pain:- What is the acceptability, safety, and effectiveness of different types of opioid analgesia for breakthrough pain in children and young people with life-limiting conditions who are having end of life care in the community?

Recommendation ID NG61/4 Question Managing breakthrough pain:- What is the acceptability, safety, and effectiveness of different types of

Research recommendation Published February 2017

Interventions to improve the acceptability and uptake of HIV testing among people at higher risk:- What interventions would be effective and cost effective among people at higher risk in the UK to increase uptake of HIV testing among people who may have undiagnosed HIV?

Recommendation ID NG60/1 Question Interventions to improve the acceptability and uptake of HIV testing among people at higher risk:- What

Research recommendation Published February 2017

Supporting healthcare professionals to offer HIV tests:- What interventions are effective and cost effective to increase the likelihood of healthcare professionals offering and recommending an HIV test and of its subsequent uptake?

Recommendation ID NG60/2 Question Supporting healthcare professionals to offer HIV tests:- What interventions are effective and cost effective

Research recommendation Published February 2017