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  1. Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities, personal, social and demographic factors, treatment type,and subsequent relapse prevention interventions) are associated with continued benefit after successful treatment for anorexia nervosa?

    Recommendation ID NG69/5 Question Maintaining benefits after successful treatment of anorexia nervosa:- What factors (including comorbidities

  2. NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting colonic polyps and may update the guidance on publication of further evidence. This should include safety and efficacy outcomes such as perforation, bleeding, the need for immediate re-intervention, inadequate resection and longer-term follow-up of patients found to have malignant disease.

    Recommendation ID IPG580/1 Question NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting

  3. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    Recommendation ID IPG628/1 Question NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive

  4. NICE encourages further research into laparoscopic insertion of a magnetic titanium ring for gastro-oesophageal reflux disease (GORD), and may update the guidance on publication of further evidence. Long-term outcome data and comparative trials with other anti-reflux surgery would be helpful.

    Recommendation ID IPG585/1 Question NICE encourages further research into laparoscopic insertion of a magnetic titanium ring for gastro-oesophageal

  5. NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty for fetal critical aortic stenosis. Further research could be in the form of controlled trials, analysis of registry data or other observational studies. It should address patient selection, timing of the intervention and the natural history of the disease.

    Recommendation ID IPG613/1 Question NICE encourages the peer-reviewed publication of all further research for percutaneous balloon valvuloplasty

  6. NICE recommended further research into the clinical effectiveness of BCM – Body Composition Monitor-guided fluid management in people with chronic kidney disease having dialysis. It noted that the ongoing BISTRO study will assess the effect of the device in people aged 18 years or over having haemodialysis. Further research should collect clinical-outcome data in the following populations:- adults (aged 18 years and over) having peritoneal dialysis- babies, children and young people (aged under 18 years) having haemodialysis- babies, children and young people (aged under 18 years) having peritoneal dialysis.

    Recommendation ID DG29/1 Question NICE recommended further research into the clinical effectiveness of BCM – Body Composition Monitor-guided

  7. 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory conditions, chronic heart failure and chronic kidney disease shows no major safety concerns. For people who are having an acute exacerbation of their chronic condition and are unable to exercise, evidence of efficacy is adequate to support the use of this procedure provided that standard arrangements are in place for clinical governance, consent and audit.   Find out  what standard arrangements mean on the NICE website . For people who are able to exercise, evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out  what only in research means on the NICE website .

    Recommendation ID IPG677 Question 1.1 Evidence on the safety of electrical stimulation to improve muscle strength in chronic respiratory

  8. Episcissors-60 show promise for mediolateral episiotomy. But there is currently not enough evidence to support the case for routine adoption in the NHS. Research is recommended to address uncertainties about the efficacy and safety of using Episcissors-60. This research should: - determine if using Episcissors-60 in addition to other care bundle measures is more effective in achieving an optimal episiotomy angle and in preventing episiotomy-related obstetric anal sphincter injuries (OASI) than standard episiotomy scissors - include patient-reported outcome measures - address potential equality considerations by ensuring patients at greatest risk of OASI are recruited - determine the relative cost of using Episcissors-60 compared with standard episiotomy scissors.

    Recommendation ID MTG47/1 Question Episcissors-60 show promise for mediolateral episiotomy. But there is currently not enough evidence

  9. Further diagnostic accuracy studies, or analyses of existing data sets, are recommended to assess the accuracy of the tests included in this assessment in the following subgroups:- people who are premenopausal- people who are postmenopausal- people with suspected early stage ovarian cancer, that is, disease apparently confined to the pelvis.Future studies should be done in populations that are representative of people with suspected ovarian cancer who are assessed in NHS secondary care.

    Recommendation ID DG31/1 Question Further diagnostic accuracy studies, or analyses of existing data sets, are recommended to assess the

  10. Further research in people who could have conventional cardiac pacemaker implantation should report the patient selection criteria and compare leadless pacemakers with conventional pacemakers. Follow-up should be for at least 5 years and outcomes should include adverse events, symptom relief, quality of life and device durability in the long-term.

    Recommendation ID IPG626/1 Question Further research in people who could have conventional cardiac pacemaker implantation should report

  11. Further research, ideally in the form of randomised controlled trials, on the safety and efficacy of prostatic urethral temporary implant insertion for lower urinary tract symptoms caused by benign prostatic hyperplasia should report details of patient selection (including prostate size and the amount of median lobe enlargement), improvement in lower urinary tract symptoms in the short term and long term, re-intervention rates, and outcome measures of sexual function using established methods.

    Recommendation ID IPG641/1 Question Further research, ideally in the form of randomised controlled trials, on the safety and efficacy of

  12. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family therapy, psychodynamic psychotherapy and interpersonal psychotherapy for adolescents (IPT‑A) compared with each other and with individual CBT in young people aged 12 to 18 years with moderate to severe depression?

    Recommendation ID NG134/3 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family