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Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine assessment and monitoring of changes in pulmonary status in people with cystic fibrosis?

Recommendation ID NG78/3 Question Monitoring pulmonary disease:- Is lung clearance index a useful and cost-effective tool for the routine

Research recommendation Published November 2018

Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative vision- and health-related quality of life, and postoperative vision-related quality of life, health-related quality of life, and self-reported postoperative improvement?

Recommendation ID NG77/3 Question Indicators and thresholds for referral for cataract surgery:- What is the association between preoperative

Research recommendation Published November 2018

Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include publication of patient-reported outcome measures and studies with long-term follow-up.

Recommendation ID IPG592 Question Further research on high-intensity focused ultrasound for symptomatic breast fibroadenoma should include

Research recommendation Published November 2018

Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung function in infants and children with cystic fibrosis?

Recommendation ID NG78/2 Question Airway clearance techniques:- How effective are daily airway clearance techniques in maintaining lung

Research recommendation Published November 2018

Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders with psychological treatments of reduced duration and reduced intensity, compared with standard treatment?

Recommendation ID NG69/2 Question Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders

Research recommendation Published October 2018

What measures would make up an effective, standardised approach to evaluation of condom distribution schemes?: How can we develop a standardised framework to evaluate condom schemes and what would be included in that evaluation?

Recommendation ID NG68/1 Question What measures would make up an effective, standardised approach to evaluation of condom distribution schemes

Research recommendation Published October 2018

What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations of behaviour change techniques can be used to help condom schemes increase condom use among different high risk groups?

Recommendation ID NG68/1 Question What behaviour change techniques are most effective as part of a condom distribution scheme?:- What combinations

Research recommendation Published October 2018

NICE encourages further research into total artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure, including well matched comparative studies. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG602/1 Question NICE encourages further research into total artificial heart implantation as a bridge to transplantation

Research recommendation Published October 2018

Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should include details of patient selection, long-term outcomes including complications, type of mesh used and method of fixation, and quality of life.

Recommendation ID IPG599/1 Question Further research on the safety of transvaginal mesh repair of anterior or posterior vaginal wall prolapse should

Research recommendation Published October 2018

Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating an intraocular pressure (IOP) of 22 or 23 mmHg in people with normal optic discs and visual fields?

Recommendation ID NG81/2 Question Treatment for people with an IOP of 22 or 23 mmHg:- What is the clinical and cost effectiveness of treating

Research recommendation Published October 2018

Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical coherence tomography (OCT) for diagnosing and monitoring glaucoma?

Recommendation ID NG81/4 Question Optical coherence tomography for glaucoma:- What is the effectiveness and cost effectiveness of optical

Research recommendation Published October 2018

Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert systems designed to monitor and improve adherence with regular inhaled maintenance therapy in people with asthma?

Recommendation ID NG80/3 Question Monitoring adherence to treatment:- What is the clinical and cost effectiveness of using electronic alert

Research recommendation Published October 2018

Improving adherence to asthma medication:- What are the most clinically and cost-effective strategies to improve medicines adherence in adults, young people and children with asthma who are non-adherent to prescribed medicines?

Recommendation ID NG80/10 Question Improving adherence to asthma medication:- What are the most clinically and cost-effective strategies

Research recommendation Published October 2018

Further research is recommended to assess the diagnostic accuracy of the tests included in this assessment when used in combination; for example sequentially.

Recommendation ID DG31/3 Question Further research is recommended to assess the diagnostic accuracy of the tests included in this assessment

Research recommendation Published October 2018

Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

Research recommendation Published October 2018

Team composition for home-based intermediate care:- How effective and cost effective are different approaches, in terms of team structure and composition, to providing home-based intermediate care for adults?

Recommendation ID NG74/2 Question Team composition for home-based intermediate care:- How effective and cost effective are different approaches

Research recommendation Published October 2018

Support needs of parents:- What are the experiences and concerns of parents of children with faltering growth?

Recommendation ID NG75/5 Question Support needs of parents:- What are the experiences and concerns of parents of children with faltering

Research recommendation Published October 2018

Support for black and minority ethnic groups:- How effective and cost effective are different approaches to supporting people from black and minority ethnic groups using intermediate care?

Recommendation ID NG74/8 Question Support for black and minority ethnic groups:- How effective and cost effective are different approaches

Research recommendation Published October 2018

Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

Recommendation ID NG74/5 Question Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that

Research recommendation Published October 2018

Pain management programmes:- Are pain management programmes a clinically and cost-effective intervention for women with endometriosis?

Recommendation ID NG73/1 Question Pain management programmes:- Are pain management programmes a clinically and cost-effective intervention

Research recommendation Published October 2018

Optimal time between referral and starting intermediate care:- What is the optimal time between referral to and starting intermediate care in terms of effectiveness and cost effectiveness and in terms of people's experiences?

Recommendation ID NG74/1 Question Optimal time between referral and starting intermediate care:- What is the optimal time between referral

Research recommendation Published October 2018

Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise) effective, compared with no specialist lifestyle interventions, for women with endometriosis?

Recommendation ID NG73/3 Question Lifestyle interventions (diet and exercise):- Are specialist lifestyle interventions (diet and exercise)

Research recommendation Published October 2018

Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness of antioxidant and zinc supplements on AMD disease progression for people with early AMD at high risk of progression in the context of a randomised controlled trial?

Recommendation ID NG82/1 Question Strategies to slow the progression of age-related macular degeneration (AMD):- What is the effectiveness

Research recommendation Published November 2018

Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial growth factor (VEGF) treatment be suspended or stoppedin people with late AMD (wet)?

Recommendation ID NG82/3 Question Stopping rules for antiangiogenic treatment for late AMD (wet):- When should anti-vascular endothelial

Research recommendation Published November 2018

Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring in people diagnosed with early AMD, indeterminate AMD or late AMD (dry) lead to earlier treatment and better long-term outcomes?

Recommendation ID NG82/5 Question Self-monitoring strategies:- Does earlier detection of the incidence of late AMD (wet active) by self-monitoring

Research recommendation Published November 2018

Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0 adenocarcinoma of the oesophagus?

Recommendation ID NG83/2 Question Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0

Research recommendation Published November 2018

Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy improve disease-free and overall survival inpeople with squamous cell carcinoma of the oesophagus?

Recommendation ID NG83/1 Question Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy

Research recommendation Published November 2018

Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support to adults after surgery with curative intent for oesophago-gastric cancer?

Recommendation ID NG83/3 Question Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support

Research recommendation Published November 2018

Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

Recommendation ID NG83/4 Question Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support

Research recommendation Published November 2018

Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective in detecting recurrent disease suitable for radical treatment in asymptomatic people who have had treatment for oesophago-gastric cancer with curative intent?

Recommendation ID NG83/5 Question Follow-up after treatment with curative intent:- Is the routine use of CT and tumour markers effective

Research recommendation Published November 2018

Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of initial haemodialysis versus initial peritoneal dialysis for people who start dialysis in an unplanned way?

Recommendation ID NG107/3 Question Acute haemodialysis versus acute peritoneal dialysis:- What is the clinical and cost effectiveness of

Research recommendation Published December 2018