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Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute management of low back pain?

Recommendation ID NG59/1 Question Pharmacological therapies:- What is the clinical and cost effectiveness of benzodiazepines for the acute

Research recommendation Published February 2017

How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period?

Recommendation ID CG192/2 Question How safe are drugs used to treat bipolar disorder in pregnancy and the postnatal period? Any explanatory

Research recommendation Published July 2017

Older people in day and residential care:- How effective are interventions in day and residential care for older people that aim to prevent infection and to reduce antimicrobial resistance?

Recommendation ID NG63/5 Question Older people in day and residential care:- How effective are interventions in day and residential care

Research recommendation Published February 2017

Workplace:- How effective are interventions in the workplace that aim to prevent infection and reduce antimicrobial resistance?

Recommendation ID NG63/4 Question Workplace:- How effective are interventions in the workplace that aim to prevent infection and reduce

Research recommendation Published February 2017

Self-sampling and self-testing:- How effective are self-sampling and self-testing in terms of accuracy of sampling, ability to reach different groups, test completion, receipt of results and subsequent care-seeking behaviour?

Recommendation ID NG60/3 Question Self-sampling and self-testing:- How effective are self-sampling and self-testing in terms of accuracy

Research recommendation Published February 2017

Radiofrequency denervation:- What is the clinical and cost effectiveness of radiofrequency denervation for chronic low back pain in the long term?

Recommendation ID NG59/3 Question Radiofrequency denervation:- What is the clinical and cost effectiveness of radiofrequency denervation

Research recommendation Published February 2017

Subsequent health assessment:- When should subsequent health assessments be carried out in prison for people serving long-term sentences?

Recommendation ID NG57/1 Question Subsequent health assessment:- When should subsequent health assessments be carried out in prison for

Research recommendation Published February 2017

Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option?

Recommendation ID NG59/5 Question Spinal fusion:- Should people with low back pain be offered spinal fusion as a surgical option? Any

Research recommendation Published February 2017

Structured clinical management interventions in probation service providers:- What is the effectiveness of structured clinical (case) management in improving mental health outcomes using interventions within probation service providers?

Recommendation ID NG66/2 Question Structured clinical management interventions in probation service providers:- What is the effectiveness

Research recommendation Published May 2017

Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different settings, for different types of tests, using different strategies (for example opt-in or opt-out approaches) and in areas and groups with different background prevalence?

Recommendation ID NG60/5 Question Cost utility:- What is the cost utility of increasing the offer or uptake of HIV testing in different

Research recommendation Published February 2017

Pharmacological management of peripheral spondyloarthritis:- What is the comparative effectiveness and cost effectiveness of standard DMARDs for managing peripheral spondyloarthritis, and is this effectiveness affected by differences in dose escalation protocols?

Recommendation ID NG65/4 Question Pharmacological management of peripheral spondyloarthritis:- What is the comparative effectiveness and

Research recommendation Published May 2017

Behavioural strategies and programmes:- What is the feasibility and effectiveness of specific behavioural strategies and programmes to reduce inappropriate antimicrobial demand and use and to prevent infections occurring and spreading?

Recommendation ID NG63/2 Question Behavioural strategies and programmes:- What is the feasibility and effectiveness of specific behavioural

Research recommendation Published February 2017

Prevalence of mental health problems:- What is the prevalence of mental health problems and associated social problems for those in contact with the criminal justice system?

Recommendation ID NG66/5 Question Prevalence of mental health problems:- What is the prevalence of mental health problems and associated

Research recommendation Published May 2017

Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective are interventions using indicator condition-targeted testing compared with other testing strategies?

Recommendation ID NG60/4 Question Indicator conditions:- What is the UK prevalence of HIV in various indicator conditions, and how effective

Research recommendation Published February 2017

Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child or young person with a life-limiting condition is likely to die within hours or days?

Recommendation ID NG61/5 Question Recognising that a child or young person may be dying:- What signs and symptoms indicate that a child

Research recommendation Published February 2017

Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What is the prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy?

Recommendation ID NG62/5 Question Prevalence of mental health problems in young people (up to the age of 25) with cerebral palsy:- What

Research recommendation Published February 2017

NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) for treating morbid obesity, particularly research examining long-term outcomes. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG569/1 Question NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy

Research recommendation Published February 2017

NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain, and that further research is needed on resource use.

Recommendation ID MTG31/2 Question NICE concluded that the cost consequences of using HumiGard in abdominal surgery are very uncertain,

Research recommendation Published April 2017

NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for sciatica and may update the guidance on publication of further evidence. Research studies should include details of patient selection, complications and long-term results.

Recommendation ID IPG570/1 Question NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for

Research recommendation Published February 2017

Further research is recommended on resource use and clinical effects associated with using the xTAG Gastrointestinal Pathogen Panel, the FilmArray GI Panel and the Faecal Pathogens B assay.

Recommendation ID DG26/1 Question Further research is recommended on resource use and clinical effects associated with using the xTAG Gastrointestinal

Research recommendation Published February 2017

Further research is recommended on alternative postpartum testing strategies that do not include cord blood typing of all babies born to rhesus-D (D) negative women.

Recommendation ID DG25/1 Question Further research is recommended on alternative postpartum testing strategies that do not include cord

Research recommendation Published February 2017

Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such as web-based interventions, online self-assessment or targeted new media, for drug misuse prevention among groups at risk in the UK?

Recommendation ID NG64/5 Question Effectiveness of digital technologies:- How effective and cost effective are digital technologies, such

Research recommendation Published May 2017

Pharmacological therapies:- What is the clinical and cost effectiveness of codeine with and without paracetamol for the acute management of low back pain?

Recommendation ID NG59/2 Question Pharmacological therapies:- What is the clinical and cost effectiveness of codeine with and without paracetamol

Research recommendation Published February 2017

Needs assessment:- In the UK, how prevalent is coexisting severe mental illness with substance misuse and what are the physical health, social care, housing or other support needs of people with this diagnosis?

Recommendation ID NG58/1 Question Needs assessment:- In the UK, how prevalent is coexisting severe mental illness with substance misuse

Research recommendation Published February 2017

Promoting health and wellbeing:- What is the most effective method for delivering health promotion activities and who should lead them (peers or professionals)?

Recommendation ID NG57/3 Question Promoting health and wellbeing:- What is the most effective method for delivering health promotion activities

Research recommendation Published February 2017

Identifying current practice and provision:- What drug misuse prevention activities are currently used in the UK for groups at risk of drug misuse?

Recommendation ID NG64/2 Question Identifying current practice and provision:- What drug misuse prevention activities are currently used

Research recommendation Published May 2017

Optimising nutritional status in children with cerebral palsy:- What is the clinical and cost effectiveness of early interventions for optimising protein, energy and micronutrient nutritional status in children with cerebral palsy?

Recommendation ID NG62/1 Question Optimising nutritional status in children with cerebral palsy:- What is the clinical and cost effectiveness

Research recommendation Published February 2017

Managing breakthrough pain:- What is the acceptability, safety, and effectiveness of different types of opioid analgesia for breakthrough pain in children and young people with life-limiting conditions who are having end of life care in the community?

Recommendation ID NG61/4 Question Managing breakthrough pain:- What is the acceptability, safety, and effectiveness of different types of

Research recommendation Published February 2017

Interventions to improve the acceptability and uptake of HIV testing among people at higher risk:- What interventions would be effective and cost effective among people at higher risk in the UK to increase uptake of HIV testing among people who may have undiagnosed HIV?

Recommendation ID NG60/1 Question Interventions to improve the acceptability and uptake of HIV testing among people at higher risk:- What

Research recommendation Published February 2017

Supporting healthcare professionals to offer HIV tests:- What interventions are effective and cost effective to increase the likelihood of healthcare professionals offering and recommending an HIV test and of its subsequent uptake?

Recommendation ID NG60/2 Question Supporting healthcare professionals to offer HIV tests:- What interventions are effective and cost effective

Research recommendation Published February 2017

Perinatal palliative care:- What impact does timely perinatal palliative care have on the experience of bereaved parents?

Recommendation ID NG61/2 Question Perinatal palliative care:- What impact does timely perinatal palliative care have on the experience of

Research recommendation Published February 2017

Managing communication difficulties in children with cerebral palsy:- What is the clinical and cost effectiveness of interventions for managing communication difficulties in children with cerebral palsy?

Recommendation ID NG62/2 Question Managing communication difficulties in children with cerebral palsy:- What is the clinical and cost effectiveness

Research recommendation Published February 2017

Association between treating infections in pregnancy and rates of cerebral palsy:- What is the association between different antibiotic regimes to treat genito-urinary and respiratory tract infections in pregnant women and subsequent rates of cerebral palsy in children?

Recommendation ID NG62/4 Question Association between treating infections in pregnancy and rates of cerebral palsy:- What is the association

Research recommendation Published February 2017

Referral criteria for people with suspected axial spondyloarthritis:- What are the optimal referral criteria for people with suspected axial spondyloarthritis?

Recommendation ID NG65/1 Question Referral criteria for people with suspected axial spondyloarthritis:- What are the optimal referral criteria

Research recommendation Published May 2017

Cost effectiveness:- What is the cost effectiveness of interventions to prevent infection and promote the appropriate use of antimicrobials?

Recommendation ID NG63/1 Question Cost effectiveness:- What is the cost effectiveness of interventions to prevent infection and promote

Research recommendation Published February 2017

What are the most effective and cost-effective interventions to challenge stereotypes and change employers' and workforce attitudes towards older employees?

Recommendation ID NG13/8 Question What are the most effective and cost-effective interventions to challenge stereotypes and change employers'

Research recommendation Published November 2016

Identification of factors associated with suicide:- What factors are associated with suicide attempts and completed suicides?

Recommendation ID NG66/6 Question Identification of factors associated with suicide:- What factors are associated with suicide attempts

Research recommendation Published May 2017

Use of image- and performance-enhancing drugs:- What are the most effective and cost effective interventions to prevent and reduce the use of image- and performance-enhancing drugs?

Recommendation ID NG64/6 Question Use of image- and performance-enhancing drugs:- What are the most effective and cost effective interventions

Research recommendation Published May 2017

What are the most effective and cost-effective interventions to maintain and improve the health and wellbeing of older employees?

Recommendation ID NG13/5 Question What are the most effective and cost-effective interventions to maintain and improve the health and wellbeing

Research recommendation Published November 2016