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Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

Addressing health inequalities:- What are the barriers to and facilitators for increasing access to community pharmacy services by underserved groups? How should health and wellbeing interventions be tailored to increase service uptake in underserved groups?

Recommendation ID NG102/3 Question Addressing health inequalities:- What are the barriers to and facilitators for increasing access to community

Research recommendation Published December 2018

People in eligible groups:- What are the important messages and how should they be tailored and delivered to encourage and sustain flu vaccination uptake in eligible groups?

Recommendation ID NG103/1 Question People in eligible groups:- What are the important messages and how should they be tailored and delivered

Research recommendation Published December 2018

Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups and removing barriers to access in order to increase their uptake of flu vaccination?

Recommendation ID NG103/2 Question Underserved groups:- What are the most effective and cost-effective ways of reaching underserved groups

Research recommendation Published December 2018

Further research in superior rectal artery embolisation for haemorrhoids should report details of patient selection, and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1 year.

Recommendation ID IPG627/1 Question Further research in superior rectal artery embolisation for haemorrhoids should report details of patient

Research recommendation Published December 2018

Health and wellbeing interventions:- How effective and cost effective are awareness raising, advice and education or behavioural support interventions delivered by community pharmacy teams to improve health and behavioural outcomes in underserved groups and the general population?

Recommendation ID NG102/2 Question Health and wellbeing interventions:- How effective and cost effective are awareness raising, advice and

Research recommendation Published December 2018

Community-based models of flu vaccination:- What models of community-based flu vaccination provision (for example, community pharmacies, community nursing and midwifery teams and outreach services) are effective and cost-effective for increasing uptake in eligible groups?

Recommendation ID NG103/5 Question Community-based models of flu vaccination:- What models of community-based flu vaccination provision

Research recommendation Published December 2018

Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and cost effective at increasing uptake of flu vaccination among front-line health and social care staff?

Recommendation ID NG103/4 Question Opt-out strategies for front-line health and social care staff:- Are opt-out strategies effective and

Research recommendation Published December 2018

Carers:- In what context is it cost effective to increase uptake of flu vaccination among carers?

Recommendation ID NG103/3 Question Carers:- In what context is it cost effective to increase uptake of flu vaccination among carers?

Research recommendation Published December 2018

Referral within a formal care pathway:- Is referral from a community pharmacy within a formal local care pathway framework more effective and cost effective than signposting alone in improving access to, and uptake of, services by underserved groups and the general population?

Recommendation ID NG102/1 Question Referral within a formal care pathway:- Is referral from a community pharmacy within a formal local care

Research recommendation Published December 2018

Chronic conditions:- What is the prevalence of disease in the UK prison population?

Recommendation ID NG57/2 Question Chronic conditions:- What is the prevalence of disease in the UK prison population? Any explanatory

Research recommendation Published November 2017

Barriers and facilitators:- What are the barriers and facilitators for young people and adults with coexisting severe mental illness and substance misuse to obtain an optimal service (including optimal time frame for delivering interventions) to meet their needs and enable their recovery?

Recommendation ID NG58/4 Question Barriers and facilitators:- What are the barriers and facilitators for young people and adults with coexisting

Research recommendation Published February 2017

Care and support for people with dementia:- What is the effect of specific interventions to support people with dementia during transition between inpatient mental health settings and community or care home settings?

Recommendation ID NG53/1 Question Care and support for people with dementia:- What is the effect of specific interventions to support people

Research recommendation Published October 2016

Care pathway:- In the UK, what is the optimal care pathway for young people and adults with coexisting severe mental illness and substance misuse?

Recommendation ID NG58/5 Question Care pathway:- In the UK, what is the optimal care pathway for young people and adults with coexisting

Research recommendation Published February 2017

Derivation of clinical decision rules in suspected sepsis:- Is it possible to derive and validate a set of clinical decision rules or a predictive tool to rule outsepsis which can be applied to patients presenting to hospital; with suspected sepsis?

Recommendation ID NG51/5 Question Derivation of clinical decision rules in suspected sepsis:- Is it possible to derive and validate a set

Research recommendation Published August 2016

For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and cost effective than usual care in preventing the development of delirium?

Recommendation ID CG103/3 Question For people in long-term care, is a multicomponent non-pharmacological intervention more clinically and

Research recommendation Published May 2019

In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics, typical antipsychotics or benzodiazepines) compared with placebo or each other for treating delirium?

Recommendation ID CG103/2 Question In people in hospital who have delirium, which is the most effective medication (atypical antipsychotics

Research recommendation Published May 2019

How common is delirium and what are its adverse outcomes in people in long-term care?

Recommendation ID CG103/4 Question How common is delirium and what are its adverse outcomes in people in long-term care? Any explanatory

Research recommendation Published May 2019

Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence of delirium and improve the recognition and recording of delirium in people in hospital?

Recommendation ID CG103/5 Question Does a staff education programme (compared with an educational leaflet or usual care) reduce the incidence

Research recommendation Published May 2019

What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation in adults with severe to profound deafness?

Recommendation ID TA566/1 Question What is the benefit of bilateral cochlear implantation compared with unilateral cochlear implantation

Research recommendation Published May 2019

NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for sciatica and may update the guidance on publication of further evidence. Research studies should include details of patient selection, complications and long-term results.

Recommendation ID IPG570/1 Question NICE encourages further research into epiduroscopic lumbar discectomy through the sacral hiatus for

Research recommendation Published February 2017

NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) for treating morbid obesity, particularly research examining long-term outcomes. NICE may update the guidance on publication of further evidence.

Recommendation ID IPG569/1 Question NICE encourages further research into single-anastomosis duodeno-ileal bypass with sleeve gastrectomy

Research recommendation Published February 2017

Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected medical emergency in the community, such as GP home visits, are most clinically and cost effective? [See the evidence review on GP-led home visits.]

Recommendation ID NG94/8 Question Primary care-led assessment models:- Which primary care-led models of assessment of people with a suspected

Research recommendation Published November 2018

Further research is needed on the benefits and consequences of detecting preclinical diabetic peripheral neuropathy.

Recommendation ID MTG38/1 Question Further research is needed on the benefits and consequences of detecting preclinical diabetic peripheral

Research recommendation Published January 2019

Extended access to GP services:- Is extended access to GP services, for example during early mornings, evenings and weekends, more clinically and cost effective than standard access?

Recommendation ID NG94/1 Question Extended access to GP services:- Is extended access to GP services, for example during early mornings

Research recommendation Published November 2018

Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically and cost effective in specific medical emergencies? [See the evidence review on standardised discharge criteria.]

Recommendation ID NG94/14 Question Standardised criteria for hospital discharge:- Are standardised criteria for hospital discharge clinically

Research recommendation Published November 2018

Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and cost effective? [See the evidence review on paramedic remote support.]

Recommendation ID NG94/7 Question Remote decision-support technologies:- Are paramedic remote decision-support technologies clinically and

Research recommendation Published November 2018

Specialised units for older people:- What is the most clinically and cost effective way to configure services to assess frail older people who present to hospital with a medical emergency?

Recommendation ID NG94/4 Question Specialised units for older people:- What is the most clinically and cost effective way to configure services

Research recommendation Published November 2018

Extended access to social care services:- What is the clinical and cost effectiveness of providing extended access to social care services, for example during early mornings and evenings, and 7 days a week?

Recommendation ID NG94/2 Question Extended access to social care services:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

Integrated patient information systems:- What is the clinical and cost effectiveness of different methods for integrating patient information throughout the emergency medical care pathway?

Recommendation ID NG94/5 Question Integrated patient information systems:- What is the clinical and cost effectiveness of different methods

Research recommendation Published November 2018

GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs within or adjoining emergency departments?

Recommendation ID NG94/3 Question GPs located in or near emergency departments:- What is the clinical and cost effectiveness of having GPs

Research recommendation Published November 2018

Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended access to community nursing, for example during evenings and weekends? [See the evidence review on community nursing.]

Recommendation ID NG94/10 Question Extended access to community nursing:- What is the clinical and cost effectiveness of providing extended

Research recommendation Published November 2018

Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing GPs with access to plain X-ray radiology or ultrasound with same-day results? [See the evidence review on GP access to radiology.]

Recommendation ID NG94/9 Question Same-day plain X-ray radiology or ultrasound:- What is the clinical and cost effectiveness of providing

Research recommendation Published November 2018

'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders' such as advanced nurse practitioners, 'physician associates' and advanced clinical practitioners in secondary care?[See the evidence review on physician extenders.]

Recommendation ID NG94/15 Question 'Physician extenders':- What is the clinical and cost effectiveness of providing 'physician extenders'

Research recommendation Published November 2018

Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in demand are the most clinically and cost effective? [See the evidence review on escalation measures.]

Recommendation ID NG94/17 Question Hospital escalation policies:- Which components of a hospital escalation policy to deal with surges in

Research recommendation Published November 2018

Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support to adults after surgery with curative intent for oesophago-gastric cancer?

Recommendation ID NG83/3 Question Nutritional support after radical surgery:- What is the optimal method of delivering nutritional support

Research recommendation Published November 2018

Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support compared to intensive dietary counselling and support along with symptom management for people having radical surgery for oesophago-gastric cancer?

Recommendation ID NG83/4 Question Jejunostomy support after radical surgery:- What is the effectiveness of long-term jejunostomy support

Research recommendation Published November 2018