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  1. The committee recommended that further studies should be done in a HPV primary screening setting. These studies should incorporate clinical outcome data and be designed to minimise verification bias. Future studies should consider measuring variability and should also take into account HPV genotyping status when possible, so that the difference in accuracy in a population vaccinated against HPV types 16 and 18 can be better understood.

    Recommendation ID DG32/1 Question The committee recommended that further studies should be done in a HPV primary screening setting. These studies

  2. Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more effective with a paediatric low dose of ICS plus a leukotriene receptor antagonist (LTRA) or with a paediatric low dose of ICS plus a long-acting beta2 agonist (LABA) in the treatment of asthma in children and young people (under 16) who have uncontrolled asthma on a paediatric low dose of ICS alone?

    Recommendation ID NG80/7 Question Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more

  3. NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting colonic polyps and may update the guidance on publication of further evidence. This should include safety and efficacy outcomes such as perforation, bleeding, the need for immediate re-intervention, inadequate resection and longer-term follow-up of patients found to have malignant disease.

    Recommendation ID IPG580/1 Question NICE encourages further research and data collection on endoscopic full thickness removal of non-lifting

  4. Methods and approaches for gathering the experiences of people who use adult social care services:- When conducting research for the purposes of service improvement, what research methods are acceptable, appropriate and effective in meaningfully gathering the views and experiences of people who use services?

    Recommendation ID NG86/1 Question Methods and approaches for gathering the experiences of people who use adult social care services:- When

  5. Monitoring asthma control using tele-healthcare:- What is the long-term (more than 12 months) clinical and cost effectiveness of using telehealthcare as a means to monitor asthma control in adults, young people and children? Methods of tele-healthcare can include telephone interview (with healthcare professional involvement) andinternet or smartphone-based monitoring support (no healthcare professional involvement).

    Recommendation ID NG80/5 Question Monitoring asthma control using tele-healthcare:- What is the long-term (more than 12 months) clinical

  6. Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis (collected from a range of sources including primary care, imaging and pulmonary rehabilitation results) be combined into a multidimensional analysis that provides accurate and useful information on prognosis?

    Recommendation ID NG115/2 Question Multidimensional assessment of outcomes- How can the individual factors associated with COPD prognosis

  7. Further research on robot-assisted kidney transplant should include studies comparing robot-assisted kidney transplant with open surgery. This should collect data on patient selection, warm ischaemia times, the need for conversion to open surgery, graft function, and long-term graft and patient survival.

    Recommendation ID IPG609/1 Question Further research on robot-assisted kidney transplant should include studies comparing robot-assisted

  8. Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should include: details of patient selection including medication use; underlying medical conditions; the intensity, duration and wavelength of light used; patient-reported outcomes; comparison with existing treatments; and the effects of repeated long-term use. NICE may update the guidance if further evidence is published.

    Recommendation ID IPG616/1 Question Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should

  9. Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.

    Recommendation ID IPG617/1 Question Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant