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  1. What are the challenges and potential solutions for UK employers and employees in micro-, small- and medium-sized organisations (which may not have easy access to additional services such as employee assistance programmes or occupational health services) in ensuring sickness policy is managed effectively and facilitating return to work?

    Recommendation ID NG146/5 Question What are the challenges and potential solutions for UK employers and employees in micro-, small- and

  2. Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What is the clinical and cost effectiveness, and optimum length, of a brief parent-training intervention for parents and carers of children and young people with attention deficit hyperactivity disorder (ADHD) aged 5 to 18 years?

    Recommendation ID NG87/1 Question Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What

  3. For children and young people with intractable cancer-related pain and pain associated with specific diseases (such as epidermolysis bullosa), what is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on to standard treatment to improve symptoms compared with treatment with standard care?

    Recommendation ID NG144/2 Question For children and young people with intractable cancer-related pain and pain associated with specific

  4. Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic accuracy of objective tests that could be used to comprisea diagnostic pathway for asthma in children and young people aged 5 to 16 (for example, exercise challenge, direct bronchial challenge with histamine or methacholine, indirect bronchial challenge with mannitol and peripheral blood eosinophil count)?

    Recommendation ID NG80/1 Question Diagnosing asthma in children and young people aged 5 to 16:- What is the acceptability and diagnostic

  5. In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation to rule out clinically significant prostate cancer? What is the diagnostic accuracy of transperineal mapping biopsy compared with transperineal non-mapping biopsy in the diagnosis of clinically significant prostate cancer?

    Recommendation ID NG131/7 Question In patients with negative MRI (Likert score 1 or 2), what is the next best diagnostic investigation

  6. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of supported digital cognitive–behavioural therapy (CBT) compared with unsupported digital CBT in young people aged 12 to 18 years with mild depression, and what are the key components of the interventions that influence effectiveness?

    Recommendation ID NG134/2 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of supported

  7. Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula is limited in quantity and quality. Therefore, although there are no major safety concerns, this procedure should only be used with special arrangements  for clinical governance, consent, and audit or research.

    Recommendation ID IPG644/1 Question Current evidence on the safety and efficacy of radially emitting laser fibre treatment of an anal fistula

  8. Data collection and analysis are recommended to monitor the effect on endoscopy and histopathology services of using virtual chromoendoscopy instead of  histopathology to assess diminutive polyps. Measures may include:- the length of time to do colonoscopies- the number of polyps sent for histopathology analysis- cost savings or workload reductions associated with reductions in histopathology.

    Recommendation ID DG28/2 Question Data collection and analysis are recommended to monitor the effect on endoscopy and histopathology services

  9. The committee recommended that data should be collected to evaluate the system impact of adopting the lead‑I ECGs on both primary and secondary care. In particular, data should be collected on how ECGs generated by the devices would be interpreted in practice, including staff time needed to interpret the ECG traces and associated costs.

    Recommendation ID DG35/2 Question The committee recommended that data should be collected to evaluate the system impact of adopting the