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  1. How can the effectiveness and cost effectiveness of condom schemes in the UK be improved for people at most risk of STIs? How can we ensure the effectiveness and cost effectiveness of the C-Card and other UK-based condom schemes for preventing sexually transmitted infections (STIs) and unintended pregnancies among groups at high risk? What are the essential components of an effective scheme?

    Recommendation ID NG68/2 Question How can the effectiveness and cost effectiveness of condom schemes in the UK be improved for people at

  2. Characteristics of a person delivering an intervention:- How do the professional characteristics of pharmacy staff affect the effectiveness and cost effectiveness of delivering information, advice, education or behavioural support to underserved groups and the general population? (Characteristics include, for example, job roles such as health champion, as well as competencies and level of training.)

    Recommendation ID NG102/4 Question Characteristics of a person delivering an intervention:- How do the professional characteristics of

  3. People with limited mobility:- How effective and cost effective are environmental changes to increase physical activity among people with limited mobility because of either enduring or life-stage specific factors (for example, small children, parents with prams or buggies, disabled people including those with sensoryimpairments and learning disabilities, older people, people with dementia and their carers)? Are effects maintained over time?

    Recommendation ID NG90/4 Question People with limited mobility:- How effective and cost effective are environmental changes to increase

  4. Use of public open spaces by particular groups:- How effective and cost effective are environmental changes to increase physical activity through use of public open spaces (including blue, green and grey spaces) by the following groups:- black and minority ethnic groups- groups with low socioeconomic status- groups experiencing other forms of disadvantage, for example carers, people with severe mental health conditions?Are effects maintained over time?

    Recommendation ID NG90/3 Question Use of public open spaces by particular groups:- How effective and cost effective are environmental changes

  5. Patient activation:- How effective and cost effective is advice, education or behavioural support offered by community pharmacy teams to improve patient activation and measures of behaviour and health changes, particularly in areas where activation levels are lower? This includes evaluating factors such as frequency, intensity and duration of the intervention.

    Recommendation ID NG102/5 Question Patient activation:- How effective and cost effective is advice, education or behavioural support offered

  6. Further research on robot-assisted kidney transplant should include studies comparing robot-assisted kidney transplant with open surgery. This should collect data on patient selection, warm ischaemia times, the need for conversion to open surgery, graft function, and long-term graft and patient survival.

    Recommendation ID IPG609/1 Question Further research on robot-assisted kidney transplant should include studies comparing robot-assisted

  7. Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic cholangiocarcinoma in the form of prospective studies, including randomised controlled trials, should address patient selection, quality-of-life outcomes and overall survival. Patient selection for the research studies should be done by amultidisciplinary team. The procedure should only be done in specialist centres by clinicians trained and experienced in managing cholangiocarcinoma.

    Recommendation ID IPG630/1 Question Further research on selective internal radiation therapy (SIRT) for unresectable primary intrahepatic

  8. Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should include: details of patient selection including medication use; underlying medical conditions; the intensity, duration and wavelength of light used; patient-reported outcomes; comparison with existing treatments; and the effects of repeated long-term use. NICE may update the guidance if further evidence is published.

    Recommendation ID IPG616/1 Question Further research on the efficacy and safety of intranasal phototherapy for allergic rhinitis should

  9. Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour in women with intact membranes when transvaginal ultrasound measurement of cervical length is needed on the accuracy of the tests and their effect on clinical outcomes. Centres using the tests to help diagnose preterm labour in women with intact membranes are encouraged to take part in studies to address the research considerations (see the guidance sections 5.12 to 5.16). Data are needed on:- the impact of gestational age on the accuracy of the tests- how the tests affect clinical decision-making- the effect of the tests on outcomes for mother and baby

    Recommendation ID DG33/1 Question Further research on the routine adoption of Actim Partus and PartoSure to help diagnose preterm labour

  10. Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant essential tremor, which could include randomised controlled trials, should address patient selection, report on functional improvement and quality of life, and provide long-term follow-up data.

    Recommendation ID IPG617/1 Question Further research on the safety of unilateral MRI-guided focused ultrasound thalamotomy for treatment-resistant