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  1. Accuracy of the SDQ for predicting social, attentional, emotional and behavioural problems in children born before 28+0 weeks' gestation What is the accuracy of the parent-completed Strengths and Difficulties Questionnaire (SDQ) for predicting social, attentional, emotional and behavioural problems in children born before 28+0weeks' gestation?

    Recommendation ID NG72/4 Question Accuracy of the SDQ for predicting social, attentional, emotional and behavioural problems in children

  2. The committee also noted that the additional evidence exploring the relationship between radiological measures of bone defects (that is, the Rickets Severity Score and the Radiographic Global Impression of Change) and health-related quality of life would help to address several key uncertainties in the economic analysis.

    Recommendation ID HST8/2 Question The committee also noted that the additional evidence exploring the relationship between radiological

  3. Additional maintenance therapy for asthma uncontrolled on a moderate dose of ICS plus LABA with or without LTRA:- What is the clinical and cost effectiveness of offering additional maintenance therapy to adults, young people and children with asthma that is uncontrolled on a moderate dose of ICS plus LABA with or without LTRA?

    Recommendation ID NG80/8 Question Additional maintenance therapy for asthma uncontrolled on a moderate dose of ICS plus LABA with or without

  4. The committee recommended that further research is needed to measure the wider effects on public health and the costs of antimicrobial stewardship associated with different classes of antibiotics used in different healthcare settings. This will help to inform the development of technologies to guide more targeted use of antibiotics and wider UK antimicrobial resistance policy.

    Recommendation ID DG38/1 Question The committee recommended that further research is needed to measure the wider effects on public health

  5. Recognition of risk and prevention of female genital mutilation:- What interventions are effective and cost effective in:- improving practitioners' recognition of children who are at risk of female genital mutilation (FGM) in the UK or overseas?- improving recognition of co-occurring forms of abuse where relevant?- preventing FGM in this group?

    Recommendation ID NG76/2 Question Recognition of risk and prevention of female genital mutilation:- What interventions are effective and

  6. Recognition of risk and prevention of 'honour-based' violence and forced marriage:- What interventions are effective and cost effective in:- improving practitioners' recognition of children who are at risk of or experiencing 'honourbased' violence and forced marriage?- preventing 'honour-based' violence and forced marriage?

    Recommendation ID NG76/3 Question Recognition of risk and prevention of 'honour-based' violence and forced marriage:- What interventions

  7. Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more effective with a paediatric low dose of ICS plus a leukotriene receptor antagonist (LTRA) or with a paediatric low dose of ICS plus a long-acting beta2 agonist (LABA) in the treatment of asthma in children and young people (under 16) who have uncontrolled asthma on a paediatric low dose of ICS alone?

    Recommendation ID NG80/7 Question Second-line maintenance therapy in children and young people (under 16):- Is maintenance therapy more

  8. Further research is recommended to assess the effect of test-guided preventive care (see section 5.1) on clinical outcomes (such as length of stay in hospital, mortality and need for renal replacement therapy and progression to chronic kidney disease). Research should be done in children, young people and adults, but specific considerations may be needed for children and young people when care differs from that for an adult population. Studies should investigate the effects of both positive and negative test results on clinical decisions and subsequent care.

    Recommendation ID DG39/2 Question Further research is recommended to assess the effect of test-guided preventive care (see section 5.1)

  9. Companies should specify patient populations in the NHS who could benefit from test-guided preventive care for acute kidney injury. Further research is then recommended in these populations to assess the clinical effectiveness of defined care bundles designed to prevent or reduce the effect of acute kidney injury in the NHS. Research should be done in children, young people and adults, but specific considerations may be needed for children and young people when care differs from that for an adult population (see  section 4.11 ).

    Recommendation ID DG39/1 Question Companies should specify patient populations in the NHS who could benefit from test-guided preventive

  10. The committee recommended that further studies should be done in a HPV primary screening setting. These studies should incorporate clinical outcome data and be designed to minimise verification bias. Future studies should consider measuring variability and should also take into account HPV genotyping status when possible, so that the difference in accuracy in a population vaccinated against HPV types 16 and 18 can be better understood.

    Recommendation ID DG32/1 Question The committee recommended that further studies should be done in a HPV primary screening setting. These studies