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  1. Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows no major safety concerns. Evidence on efficacy is inadequate in quality. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE website.

    Recommendation ID IPG692/1 Question Evidence on the safety of repetitive short-pulse transscleral cyclophotocoagulation for glaucoma shows

  2. Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy to the standard AEDs in the treatment of newly diagnosed epilepsy? Focal seizures: carbamazepine, eslicarbazepine acetate, lacosamide, lamotrigine, levetiracetam, pregabalin  and zonisamide. Generalised seizures: lamotrigine, levetiracetam, sodium valproate and zonisamide.

    Recommendation ID CG137/1 Question Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy

  3. Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation devices to improve outcomes after stroke or subarachnoid haemorrhage is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG701/1 Question Evidence on the safety and efficacy of inducing and maintaining normothermia using temperature modulation

  4. Technologies for preventing and treating impaired hypoglycaemia awareness in adults with type 1 diabetes: For adults with type 1 diabetes, what are the optimum technologies (such as insulin pump therapy and/or continuous glucose monitoring, partially or fully automated insulin delivery, and behavioural, psychological and educational interventions) and how are they best used, in terms of clinical and cost effectiveness, for preventing and treating impaired hypoglycaemia awareness?

    Recommendation ID NG17/5 Question Technologies for preventing and treating impaired hypoglycaemia awareness in adults with type 1 diabetes:

  5. Oral teicoplanin compared with oral vancomycin or oral fidaxomicin for treating Clostridioides difficile infection: What is the clinical effectiveness, cost effectiveness and safety of oral teicoplanin 100 mg to 200 mg twice a day for 7 to 14 days compared with oral vancomycin or oral fidaxomicin for treating C. difficile infection in adults?

    Recommendation ID NG199/1 Question Oral teicoplanin compared with oral vancomycin or oral fidaxomicin for treating Clostridioides difficile

  6. Further evidence to address uncertainties about the relative clinical and cost effectiveness of UroLift compared with Rezum, especially in the NHS, would be welcome. This should include: • exploring long-term clinical outcomes and reintervention rates after UroLift • assessing the suitability of UroLift for prostates larger than 80 ml and for those with an obstructive median lobe.

    Recommendation ID MTG58/1 Question Further evidence to address uncertainties about the relative clinical and cost effectiveness of UroLift

  7. The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term safety concerns. Evidence on long-term safety andefficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means onthe NICE interventional procedures guidance page.

    Recommendation ID IPG696/1 Question The evidence on transvaginal laser therapy for stress urinary incontinence does not show any short-term

  8. The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety concerns. Evidence on long-term safety and efficacy is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG697/1 Question The evidence on transvaginal laser therapy for urogenital atrophy does not show any short-term safety

  9. Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart failure is inadequate in quality and quantity.Therefore, this procedure should only be used in the context of research. Find out what only in research means on the NICE interventional procedures guidance page.

    Recommendation ID IPG694/1 Question Evidence on the safety and efficacy of permanent His-bundle pacemaker implantation for treating heart

  10. Are comprehensive early interventions that combine multiple elements and are delivered by parents and teachers (for example, the Learning Experiences – an Alternative Program for Preschoolers and their Parents [LEAP] model) effective in managing the core features of autism and coexisting difficulties (such as adaptive behaviour and developmental skills) in pre‑school children?

    Recommendation ID CG170/4 Question Are comprehensive early interventions that combine multiple elements and are delivered by parents and

  11. Rate-control drug treatment for people aged 75 and over with atrial fibrillation: What is the comparative effectiveness of the 3 main drug classes used for rate control (beta‑blockers, calcium‑channel blockers and digoxin) in people aged 75 and over with atrial fibrillation in controlling symptoms, improving quality of life and reducing morbidity and mortality?

    Recommendation ID NG196/6 Question Rate-control drug treatment for people aged 75 and over with atrial fibrillation: What is the comparative