Updating results

In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

Research recommendation Published November 2019

What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies

Recommendation ID CG71/5 Question What are the implications of FH for the safety of a mother during pregnancy and what are the risks of

Research recommendation Published November 2019

What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems?

Recommendation ID NG19/7 Question What is the effectiveness of different footwear, insoles and orthoses in the prevention of foot problems

Research recommendation Published November 2019

What strategies may be useful in the prevention of Charcot arthropathy?

Recommendation ID NG19/4 Question What strategies may be useful in the prevention of Charcot arthropathy? Any explanatory notes(if

Research recommendation Published November 2019

In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive of GORD, what patient characteristics, risk factors and predictors indicate when endoscopy is needed to exclude Barrett's oesophagus?

Recommendation ID CG184/1 Question In people who experience symptoms of gastro-oesophageal reflux disease (GORD) or symptoms suggestive

Research recommendation Published November 2019

What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?

Recommendation ID CG71/4 Question What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous

Research recommendation Published November 2019

What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children with FH?

Recommendation ID CG71/3 Question What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children

Research recommendation Published November 2019

What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who are treated with statin therapy?

Recommendation ID CG71/2 Question What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH

Research recommendation Published November 2019

Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG660/1 Question Current evidence on the safety and efficacy of implant insertion for prominent ears is inadequate in

Research recommendation Published November 2019

Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated with developing the disease and is such monitoring cost effective?

Recommendation ID NG19/1 Question Does intensive monitoring of people at risk of diabetic foot disease reduce the morbidity associated

Research recommendation Published November 2019

Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure control and resolution of the hypsarrhythmic EEG influence the long-term developmental and cognitive outcomes more than the underlying cause of the spasms?

Recommendation ID CG137/3 Question Does treatment response relate to cause in infantile spasms? Does early treatment success in seizure

Research recommendation Published November 2019

What is the effectiveness of laparoscopic fundoplication compared with medical management in people with GORD that does not respond to optimal proton pump inhibitor (PPI) treatment?

Recommendation ID CG184/2 Question What is the effectiveness of laparoscopic fundoplication compared with medical management in people

Research recommendation Published November 2019

Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon technique) for locally advanced rectal cancer is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG659/1 Question Current evidence on the safety and efficacy of low-energy contact X‑ray brachytherapy (the Papillon

Research recommendation Published November 2019

What are the symptoms of GORD in infants, children and young people with a neurodisability?

Recommendation ID NG1/1 Question What are the symptoms of GORD in infants, children and young people with a neurodisability? Any

Research recommendation Published November 2019

When and with what criteria should people with diabetes be referred to the foot protection service or the multidisciplinary foot care service?

Recommendation ID NG19/2 Question When and with what criteria should people with diabetes be referred to the foot protection service or

Research recommendation Published November 2019

What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers who have taken AEDs during pregnancy?

Recommendation ID CG137/5 Question What is the malformation rate and longer term neurodevelopmental outcome of children born to mothers

Research recommendation Published November 2019

Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe emphysema is inadequate in quantity and quality. Therefore the procedure should only be used in the context of  research .

Recommendation ID IPG652/1 Question Current evidence on the safety and efficacy of bronchoscopic thermal vapour ablation for upper-lobe

Research recommendation Published November 2019

The evidence on cardiac contractility modulation device implantation for heart failure raises no major safety concerns. However, the evidence on efficacy is inadequate in quantity and quality. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG655 Question The evidence on cardiac contractility modulation device implantation for heart failure raises no major

Research recommendation Published November 2019

What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?

Recommendation ID CG71/6 Question What is the utility of routine cardiovascular evaluation for asymptomatic people with FH? Any

Research recommendation Published November 2019

What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants with frequent regurgitation associated with marked distress?

Recommendation ID NG1/2 Question What is the effectiveness and cost effectiveness of a trial of hydrolysed formula in formula‑fed infants

Research recommendation Published November 2019

What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Recommendation ID NG19/5 Question What is the clinical effectiveness of different dressing types in treating diabetic foot problems?

Research recommendation Published November 2019

What is the most effective and safest AED to treat: established (usually lasting longer than 30 minutes) convulsive status epilepticus refractory convulsive status epilepticus?

Recommendation ID CG137/4 Question What is the most effective and safest AED to treat: established (usually lasting longer than

Research recommendation Published November 2019

What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum primary care, or for people whose symptoms return after surgery?

Recommendation ID CG184/4 Question What specialist management is effective for people whose symptoms do not respond to PPIs despite optimum

Research recommendation Published November 2019

What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in people with uninvestigated dyspepsia that does not respond to PPIs or H 2   receptor antagonists (H 2 RAs) despite optimum primary care?

Recommendation ID CG184/5 Question What specialist investigations should be conducted to exclude a diagnosis of functional dyspepsia in

Research recommendation Published November 2019

Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate in quality and quantity. Therefore, this procedure should only be used in the context of  research .

Recommendation ID IPG661/1 Question Evidence on the safety and efficacy of high-intensity focused ultrasound for glaucoma is inadequate

Research recommendation Published November 2019

What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary care case finding?

Recommendation ID CG71/1 Question What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary

Research recommendation Published November 2019

Melanoma

Everything NICE has said assessing and managing melanoma in an interactive flowchart

NICE Pathway Published July 2015 Last updated November 2019

Urogenital conditions

Everything NICE has said on urogenital conditions in an interactive flowchart

NICE Pathway Published June 2015 Last updated November 2019

Excess winter deaths and illnesses associated with cold homes

Everything NICE has said on reducing the risk of excess winter deaths and illness associated with cold homes in an interactive flowchart

NICE Pathway Published March 2015 Last updated November 2019

For women who are having medical abortion between 10 +1   and 12 +0  weeks, what is the efficacy and acceptability of expulsion at home compared with expulsion in a clinical setting?

Recommendation ID NG140/4 Question For women who are having medical abortion between 10 +1 and 12 +0 weeks, what is the efficacy and

Research recommendation Published November 2019

Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing an accurate diagnosis of active respiratory TB in children and young people withsuspected active TB?

Recommendation ID NG33/2 Question Apart from culture, what other diagnostic tests or combinations of tests are effective inestablishing

Research recommendation Published November 2019

What effects does isolation have on the quality of life of people being treated for TB?

Recommendation ID NG33/4 Question What effects does isolation have on the quality of life of people being treated for TB? Any explanatory

Research recommendation Published November 2019

Which people with extreme hypertension (220/120 mmHg or higher) or emergency symptoms should be referred for same-day hospital specialist assessment?

Recommendation ID NG136/6 Question Which people with extreme hypertension (220/120 mmHg or higher) or emergency symptoms should be referred

Research recommendation Published November 2019

What is the most accurate prenatal screening marker for TAPS, including middle cerebral artery peak systolic velocity (MCA‑PSV)?

Recommendation ID NG137/1 Question What is the most accurate prenatal screening marker for TAPS, including middle cerebral artery peak

Research recommendation Published November 2019

What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Recommendation ID NG140/1 Question What is the optimal antibiotic prophylaxis regimen for women who are having a surgical abortion?

Research recommendation Published November 2019

Should women having a surgical abortion up to and including 10 +0  weeks' gestation have anti-D prophylaxis if they are RhD (or D) negative?

Recommendation ID NG140/3 Question Should women having a surgical abortion up to and including 10 +0 weeks' gestation have anti-D prophylaxis

Research recommendation Published November 2019

What are the most effective and acceptable methods of cervical priming before dilatation and evacuation after 16 +0  weeks' gestation?

Recommendation ID NG140/2 Question What are the most effective and acceptable methods of cervical priming before dilatation and evacuation

Research recommendation Published November 2019

What is the optimal regimen for general anaesthesia for women having surgical abortion?

Recommendation ID NG140/7 Question What is the optimal regimen for general anaesthesia for women having surgical abortion? Any explanatory

Research recommendation Published November 2019

What local anaesthetic techniques are most effective for women having surgical abortion?

Recommendation ID NG140/5 Question What local anaesthetic techniques are most effective for women having surgical abortion? Any

Research recommendation Published November 2019