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  1. Twin and triplet pregnancy

    Everything NICE has said on managing twin and triplet pregnancies in the antenatal and intrapartum period in an interactive flowchart

  2. Acute kidney injury

    Everything NICE has said on preventing, detecting and managing acute kidney injury in an interactive flowchart

  3. Unintentional injuries among under-15s

    Preventing unintentional injuries among under-15s in the home, on the road and in outdoor play and leisure environments.

  4. Familial breast cancer

    Everything NICE has said on assessing and managing familial breast cancer and related risks in people with a family history in an interactive flowchart

  5. Bipolar disorder

    Everything NICE has said on recognising, assessing and managing bipolar disorder in children, young people and adults in an interactive flowchart

  6. Social anxiety disorder

    Everything NICE has said on recognising, assessing and treating social anxiety disorder in children, young people and adults in an interactive flowchart

  7. Impetigo

    Everything NICE has said on the use of antiseptics and antibiotics to manage impetigo in an interactive flowchart

  8. Neonatal parenteral nutrition

    Everything NICE has said on parenteral nutrition (intravenous feeding) for newborn babies in an interactive flowchart.

  9. Aortic aneurysms

    Everything NICE has said on aortic aneurysms in an interactive flowchart

  10. Abdominal aortic aneurysm

    Everything NICE has said on diagnosing and managing abdominal aortic aneurysm in an interactive flowchart

  11. Bedwetting in children and young people

    Everything NICE has said on assessing and managing bedwetting (nocturnal enuresis) in children and young people under 19 in an interactive flowchart

  12. Heavy menstrual bleeding

    Everything NICE has said on assessing and managing heavy menstrual bleeding in an interactive flowchart

  13. Lung cancer

    Everything NICE has said on diagnosing and treating lung cancer in an interactive flowchart

  14. Postnatal care

    Everything NICE has said on the essential care that every woman and her baby should receive in the first 6–8 weeks after birth in an interactive flowchart

  15. Respiratory conditions

    Everything NICE has said on respiratory conditions in an interactive flowchart

  16. Generalised anxiety disorder

    Everything NICE has said on managing generalised anxiety disorder in adults in primary, secondary and community care in an interactive flowchart

  17. NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive bladder cancer. Research should include randomised controlled trials, which stratify patients by risk and give adequate follow-up. They should report frequency of adverse events, patientreported outcome measures, overall and disease-free survival and quality of life.

    Recommendation ID IPG628/1 Question NICE encourages further research into intravesical microwave hyperthermia and chemotherapy for non-muscle-invasive

  18. NICE encourages further research into radiofrequency treatment for haemorrhoids, preferably randomised controlled trials. It may update the guidance on publication of further evidence. Outcomes should include pain, secondary haemorrhage, recurrence rate, the need for repeat procedures and quality-of-life measures. Details of patient selection should also be reported.

    Recommendation ID IPG589/1 Question NICE encourages further research into radiofrequency treatment for haemorrhoids, preferably randomised

  19. NICE recommended that data on the effect of BCM – Body Composition Monitor-guided monitoring on health-related quality of life is collected and published. Prospective within-patient studies, which record quality of life and symptoms before and after having BCM – Body Composition Monitor-guided fluid management should be considered.

    Recommendation ID DG29/2 Question NICE recommended that data on the effect of BCM – Body Composition Monitor-guided monitoring on health-related

  20. NICE recommended that further research should be designed to generate robust evidence of the clinical- and cost-effectiveness of Holoclar for treating both eyes in people with bilateral limbal stem cell deficiency after eye burns if they do not have enough tissue for a conjunctival limbal autograft. The study should recruit people with bilateral disease and evaluate the effectiveness of treatment in both eyes. Outcomes should include transplant success and assessments of health-related quality of life using a generic preference-based measure.

    Recommendation ID TA467/2 Question NICE recommended that further research should be designed to generate robust evidence of the clinical-

  21. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    Recommendation ID TA467/1 Question NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness

  22. NICE considered that further research is needed to determine whether faecal haemoglobin levels are influenced by age, sex and medicines that increase the risk of gastrointestinal bleeding. It noted that these data could be used to further develop risk scores that include variables such as age, sex and symptoms to help determine pre-test probability. The data could also be combined with faecal haemoglobin concentration to refine management after the use of faecal immunochemical tests in primary care.

    Recommendation ID DG30/1 Question NICE considered that further research is needed to determine whether faecal haemoglobin levels are influenced

  23. Most women will need to use contraception for more than 30 years. Patterns of contraceptive use vary with age, ethnicity, marital status, fertility intention, education and lifestyle. Large prospective cohort studies are needed to identify: patterns of use (initiation, continuation and switching between methods) of LARC methods compared with non‑LARC methods factors that influence the patterns of use of LARC.

    Recommendation ID CG30/2 Question Most women will need to use contraception for more than 30 years. Patterns of contraceptive use vary

  24. What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family therapy, psychodynamic psychotherapy and interpersonal psychotherapy for adolescents (IPT‑A) compared with each other and with individual CBT in young people aged 12 to 18 years with moderate to severe depression?

    Recommendation ID NG134/3 Question What is the clinical and cost effectiveness, post-treatment and at longer-term follow‑up, of family

  25. What is the most clinically and cost-effective follow‑up protocol for people with prostate cancer who have had radical treatment, with specific regard to risk stratification, duration of follow‑up, frequency of follow‑up appointments, the type of examination or blood tests, and the roles of primary and secondary care in follow‑up?

    Recommendation ID NG131/2 Question What is the most clinically and cost-effective follow‑up protocol for people with prostate cancer who

  26. What is the most suitable surveillance protocol (including the role of digital rectal examination [DRE] and prostate-specific antigen [PSA] measures) for people for whom active surveillance is appropriate, as assessed by multiparametric MRI and biopsy, when there are no clinical concerns during follow‑up?

    Recommendation ID NG131/1 Question What is the most suitable surveillance protocol (including the role of digital rectal examination [DRE]