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What methods and techniques help secondary schools and providers to effectively engage with parents and carers as part of a whole-school approach to promote and support alcohol education?

Recommendation ID NG135/6 Question What methods and techniques help secondary schools and providers to effectively engage with parents

Research recommendation Published October 2019

What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?

Recommendation ID CG137/2 Question What are the initial and add-on AEDs of choice in the treatment of the epilepsy syndromes with onset

Research recommendation Published November 2019

Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits of burosumab would also be valuable.

Recommendation ID HST8/3 Question Evidence on the progression of X-linked hypophosphataemia (XLH) over time and the long-term benefits

Research recommendation Published March 2019

Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after treatment improve overall survival/outcomes inmolecularly stratified glioma?

Recommendation ID NG99/4 Question Managing glioma: early detection of recurrence after treatment:- Does early detection of recurrence after

Research recommendation Published December 2018

Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative care improve outcomes for people with glioblastomas in comparison with standard oncology care?

Recommendation ID NG99/3 Question Managing glioma: early referral to palliative care for glioblastoma:- Does early referral to palliative

Research recommendation Published December 2018

Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects maintained over time?

Recommendation ID NG90/5 Question Reducing car ownership:- Does reducing car use or ownership change physical activity levels? Are effects

Research recommendation Published November 2018

Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant temozolomide to radiotherapy improve overall survival in patients with IDH wildtype grade II glioma?

Recommendation ID NG99/1 Question Managing glioma: management of IDH wildtype grade II glioma:- Does the addition of concurrent and adjuvant

Research recommendation Published December 2018

The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices in primary care for people with signs or symptoms of atrial fibrillation, and an irregular pulse, increases the number of people with atrial fibrillation (including paroxysmal) detected,  ompared with current practice (that is, a 12‑lead ECG done later). The committee considered the feasibility of collecting data to see if using the lead‑I ECG devices increased the detection of atrial fibrillation that would be missed if only 12‑lead ECGs done later were available. It noted that even if a lead‑I ECG is used and atrial fibrillation is detected, a subsequent 12‑lead ECG would still be done to check for structural cardiac abnormalities and inform further management decisions. The committee concluded that practices using lead‑I ECG devices could determine the number of additional cases of atrial fibrillation detected by the devices. This can be done by identifying people with a confirmed positive lead‑I ECG for atrial fibrillation who subsequently had a 12‑lead ECG that was negative because the atrial fibrillation had stopped. The committee also considered that data collected on the time between the initial lead‑I ECG and the subsequent 12‑lead ECG would be useful.

Recommendation ID DG35/1 Question The committee recommended further research to determine if using the lead‑I electrocardiogram (ECG) devices

Research recommendation Published October 2019

Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost effective for improving parenting and preventing recurrence of child abuse and neglect in families where child abuse or neglect has occurred?

Recommendation ID NG76/14 Question Effectiveness of web-based parenting programmes:- Are web-based parenting programmes effective and cost

Research recommendation Published October 2018

Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost effective in the UK to prevent abuse and neglect of children and young people in families at risk of, or showing early signs of, abuse and neglect?

Recommendation ID NG76/5 Question Effective prevention of child abuse and neglect in the UK:- What interventions are effective and cost

Research recommendation Published October 2018

What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease (Los Angeles classification grade C/D or Savary–Miller grade 3/4): to reduce severe oesophagitis to control symptoms as maintenance therapy?

Recommendation ID CG184/3 Question What is the clinical effectiveness of double-dose PPIs in people with severe erosive reflux disease

Research recommendation Published November 2019

Which of the electronic information-sharing systems perform best for the care of people approaching the end of their life?

Recommendation ID NG142/2 Question Which of the electronic information-sharing systems perform best for the care of people approaching

Research recommendation Published November 2019

Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes including bestcorrected visual acuity and quality of life, of different review frequencies/strategies for people at risk of progression to late AMD (wet active)?

Recommendation ID NG82/4 Question Frequency of monitoring:- What is the long-term cost effectiveness, in terms of patient-relevant outcomes

Research recommendation Published November 2018

In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing acid reflux as determined by oesophageal pH monitoring?

Recommendation ID NG1/3 Question In infants, children and young people with overt or occult reflux, is fundoplication effective in reducing

Research recommendation Published November 2019

Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic monitoring of TNF‑alpha inhibitors in people with rheumatoid arthritis.

Recommendation ID DG36/1 Question Further primary research is recommended on the clinical effectiveness of using ELISA tests for therapeutic

Research recommendation Published October 2019

Further research in low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk of non-healing should include details of patient selection, fracture site, and risk factors and comorbidities that delay fracture healing.

Recommendation ID IPG622/1 Question Further research in low-intensity pulsed ultrasound to promote healing of fresh fractures at high risk

Research recommendation Published December 2018

Further research in superior rectal artery embolisation for haemorrhoids should report details of patient selection, and follow-up efficacy (including symptom relief), need for subsequent treatments, quality of life and safety outcomes for at least 1 year.

Recommendation ID IPG627/1 Question Further research in superior rectal artery embolisation for haemorrhoids should report details of patient

Research recommendation Published December 2018

What is the clinical and cost effectiveness of dosimetry-guided radioactive iodine strategies for hyperthyroidism?

Recommendation ID NG145/5 Question What is the clinical and cost effectiveness of dosimetry-guided radioactive iodine strategies for hyperthyroidism

Research recommendation Published February 2020

Duration and intensity of home-based intermediate care:- How effective and cost effective are different approaches, in terms of duration and intensity, to providing home-based intermediate care for adults?

Recommendation ID NG74/7 Question Duration and intensity of home-based intermediate care:- How effective and cost effective are different

Research recommendation Published October 2018

Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders with psychological treatments of reduced duration and reduced intensity, compared with standard treatment?

Recommendation ID NG69/2 Question Duration and intensity of psychological treatment:- What is the effectiveness of treating eating disorders

Research recommendation Published October 2018

Early help home visiting:- What are the components of effective home visiting programmes for preventing child abuse and neglect in families of children and young people at risk of child abuse and neglect in the UK?

Recommendation ID NG76/4 Question Early help home visiting:- What are the components of effective home visiting programmes for preventing

Research recommendation Published October 2018

What are the benefits of planned, regular community-based reviews compared with as-required review of non-cancer patients approaching the end of their life?

Recommendation ID NG142/3 Question What are the benefits of planned, regular community-based reviews compared with as-required review of

Research recommendation Published November 2019

Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Recommendation ID NG75/4 Question Frequency of monitoring:- How frequently should children be measured to identify faltering growth?

Research recommendation Published October 2018

Psychotic symptoms (hallucinations and delusions):- What is the effectiveness of rivastigmine compared with atypical antipsychotic drugs for treating psychotic symptoms (particularly hallucinations and delusions) associated with Parkinson's disease?

Recommendation ID NG71/3 Question Psychotic symptoms (hallucinations and delusions):- What is the effectiveness of rivastigmine compared

Research recommendation Published October 2018

Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual changes in a population with cataracts?

Recommendation ID NG77/2 Question Quality of life in cataract surgery:- What vision-specific, quality-of-life measures best capture visual

Research recommendation Published October 2018

Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy improve disease-free and overall survival inpeople with squamous cell carcinoma of the oesophagus?

Recommendation ID NG83/1 Question Radical treatment of squamous cell carcinoma of the oesophagus:- Does the addition of surgery to chemoradiotherapy

Research recommendation Published November 2018

Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0 adenocarcinoma of the oesophagus?

Recommendation ID NG83/2 Question Radical treatment of T1bN0 adenocarcinoma of the oesophagus:- What is the optimal treatment for T1bN0

Research recommendation Published November 2018

What interventions are effective and cost effective at raising awareness of the health risks of damp and mould in the home?

Recommendation ID NG149/5 Question What interventions are effective and cost effective at raising awareness of the health risks of damp

Research recommendation Published February 2020

Rapid eye movement sleep behaviour disorder treatment:- What is the best first-line treatment for rapid eye movement sleep behaviour disorder (RBD) in people with Parkinson's disease?

Recommendation ID NG71/4 Question Rapid eye movement sleep behaviour disorder treatment:- What is the best first-line treatment for rapid

Research recommendation Published October 2018

Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that lasts longer than 6 weeks?

Recommendation ID NG74/5 Question Reablement:- How effective and cost effective are repeated periods of reablement, and reablement that

Research recommendation Published October 2018

What is the effectiveness, cost effectiveness and acceptability of social prescribing for carers?

Recommendation ID NG150/5 Question What is the effectiveness, cost effectiveness and acceptability of social prescribing for carers?

Research recommendation Published February 2020

What is the effectiveness, cost effectiveness and acceptability of carer passport schemes?

Recommendation ID NG150/4 Question What is the effectiveness, cost effectiveness and acceptability of carer passport schemes? Any

Research recommendation Published February 2020

Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of acute physical risk for people with eating disorders?

Recommendation ID NG69/3 Question Predictors of acute physical risk:- What clinical and biochemical markers are the best predictors of

Research recommendation Published October 2018

What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies

Recommendation ID CG71/5 Question What are the implications of FH for the safety of a mother during pregnancy and what are the risks of

Research recommendation Published November 2019

What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic with an anaesthetic agent, for premedication in preterm babies requiring elective or semi-elective intubation?

Recommendation ID NG124/5 Question What is the most effective combination of an analgesic with a neuromuscular blocker, or an analgesic

Research recommendation Published August 2019