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  1. Aspirin prophylaxis for people with fragility fractures of the pelvis, hip or proximal femur:- What is the clinical and cost effectiveness of aspirin alone versus other pharmacological and/or mechanical prophylaxis strategies (alone or in combination) for people with fragility fractures of the pelvis, hip or proximal femur?

    Recommendation ID NG89/4 Question Aspirin prophylaxis for people with fragility fractures of the pelvis, hip or proximal femur:- What is

  2. Effective components of integrated regional services for people with a learning disability and behaviour that challenges:- What are the effective components of an integrated regional service for people with a learning disability and behaviour that challenges across health and social care (including pooling budgetsand other resources)?What are the barriers and facilitators to pooling budgets and other resources across regions?

    Recommendation ID NG93/4 Question Effective components of integrated regional services for people with a learning disability and behaviour

  3. NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness evidence evaluating the use of Holoclar in both eyes in bilateral patients. The committee was aware of the ongoing HOLOCORE trial which is recruiting both unilateral and bilateral patients, but only evaluates the success of a second transplant in 1 eye rather than transplant success in both eyes.

    Recommendation ID TA467/1 Question NICE agreed that further research was needed because there is currently no clinical- or cost-effectiveness

  4. NICE considered that further research is needed to determine whether faecal haemoglobin levels are influenced by age, sex and medicines that increase the risk of gastrointestinal bleeding. It noted that these data could be used to further develop risk scores that include variables such as age, sex and symptoms to help determine pre-test probability. The data could also be combined with faecal haemoglobin concentration to refine management after the use of faecal immunochemical tests in primary care.

    Recommendation ID DG30/1 Question NICE considered that further research is needed to determine whether faecal haemoglobin levels are influenced

  5. What are the challenges and potential solutions for UK employers and employees in micro-, small- and medium-sized organisations (which may not have easy access to additional services such as employee assistance programmes or occupational health services) in ensuring sickness policy is managed effectively and facilitating return to work?

    Recommendation ID NG146/5 Question What are the challenges and potential solutions for UK employers and employees in micro-, small- and

  6. Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What is the clinical and cost effectiveness, and optimum length, of a brief parent-training intervention for parents and carers of children and young people with attention deficit hyperactivity disorder (ADHD) aged 5 to 18 years?

    Recommendation ID NG87/1 Question Children and young people aged 5 to 18 years – brief, group-based, ADHDfocused, parent-training intervention What

  7. For children and young people with intractable cancer-related pain and pain associated with specific diseases (such as epidermolysis bullosa), what is the clinical and cost effectiveness of cannabis-based medicinal products as an add-on to standard treatment to improve symptoms compared with treatment with standard care?

    Recommendation ID NG144/2 Question For children and young people with intractable cancer-related pain and pain associated with specific

  8. Data collection and analysis are recommended to monitor the effect on endoscopy and histopathology services of using virtual chromoendoscopy instead of  histopathology to assess diminutive polyps. Measures may include:- the length of time to do colonoscopies- the number of polyps sent for histopathology analysis- cost savings or workload reductions associated with reductions in histopathology.

    Recommendation ID DG28/2 Question Data collection and analysis are recommended to monitor the effect on endoscopy and histopathology services

  9. The committee recommended that data should be collected to evaluate the system impact of adopting the lead‑I ECGs on both primary and secondary care. In particular, data should be collected on how ECGs generated by the devices would be interpreted in practice, including staff time needed to interpret the ECG traces and associated costs.

    Recommendation ID DG35/2 Question The committee recommended that data should be collected to evaluate the system impact of adopting the

  10. Accuracy of the SDQ for predicting social, attentional, emotional and behavioural problems in children born before 28+0 weeks' gestation What is the accuracy of the parent-completed Strengths and Difficulties Questionnaire (SDQ) for predicting social, attentional, emotional and behavioural problems in children born before 28+0weeks' gestation?

    Recommendation ID NG72/4 Question Accuracy of the SDQ for predicting social, attentional, emotional and behavioural problems in children